rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-15
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pubmed:abstractText |
There is an urgent need to identify the molecular factors involved in osteoblast proliferation and differentiation in order to improve bone formation and treat bone disease. Recent studies demonstrate that many 'axon guidance' molecules play important roles in the development and remodeling of bone through their actions regulating osteoblast or osteoclast differentiation. The expressions and roles in bone tissue of the neuron guidance molecules slit and robo have not been reported previously. The objective of the current study is to investigate the expression and the roles of slit and robo in osteoblastic cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/ROBO2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Slit homolog 2 protein,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/roundabout protein
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pubmed:status |
MEDLINE
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pubmed:issn |
1422-6421
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-80
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pubmed:meshHeading |
pubmed-meshheading:19033678-Animals,
pubmed-meshheading:19033678-Cell Differentiation,
pubmed-meshheading:19033678-Cell Line,
pubmed-meshheading:19033678-Gene Expression Regulation,
pubmed-meshheading:19033678-Humans,
pubmed-meshheading:19033678-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19033678-Metabolic Networks and Pathways,
pubmed-meshheading:19033678-Mice,
pubmed-meshheading:19033678-Nerve Tissue Proteins,
pubmed-meshheading:19033678-Osteoblasts,
pubmed-meshheading:19033678-RNA, Messenger,
pubmed-meshheading:19033678-Rats,
pubmed-meshheading:19033678-Receptors, Immunologic,
pubmed-meshheading:19033678-rhoA GTP-Binding Protein
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pubmed:year |
2009
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pubmed:articleTitle |
Regulation of osteoblast differentiation by slit2 in osteoblastic cells.
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pubmed:affiliation |
Orthopaedic Cellular Molecular Biology Laboratory, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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