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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-15
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pubmed:abstractText |
The potential detrimental effects of glucose degradation products (GDPs) contained in peritoneal dialysis fluids (PDFs) on peritoneal mesothelial cells (PMCs) may impair intraperitoneal homeostasis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A recent study showed that 3,4-dideoxyglucosone-3-ene (3,4-DGE) was the most strongly cytotoxic among all identified GDPs in PDFs. The present study examined the effects of clinically relevant concentrations of 3,4-DGE on the proliferative capacity of PMCs and oxidative injury to them.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1460-2385
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1436-42
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pubmed:meshHeading |
pubmed-meshheading:19033251-Apoptosis,
pubmed-meshheading:19033251-Cell Proliferation,
pubmed-meshheading:19033251-Cells, Cultured,
pubmed-meshheading:19033251-Dialysis Solutions,
pubmed-meshheading:19033251-Dose-Response Relationship, Drug,
pubmed-meshheading:19033251-Epithelial Cells,
pubmed-meshheading:19033251-Glutathione,
pubmed-meshheading:19033251-Glycogen Phosphorylase,
pubmed-meshheading:19033251-Humans,
pubmed-meshheading:19033251-Oxidation-Reduction,
pubmed-meshheading:19033251-Peritoneal Dialysis, Continuous Ambulatory,
pubmed-meshheading:19033251-Peritoneum,
pubmed-meshheading:19033251-Pyrones
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pubmed:year |
2009
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pubmed:articleTitle |
Glutathione depletion as a mechanism of 3,4-dideoxyglucosone-3-ene-induced cytotoxicity in human peritoneal mesothelial cells: role in biocompatibility of peritoneal dialysis fluids.
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pubmed:affiliation |
Research & Development, JMS Co. Ltd, 12-17 Kako-machi, Naka-ku, Hiroshima, Japan. t-yamamoto@jms.cc
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pubmed:publicationType |
Journal Article
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