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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
48
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pubmed:dateCreated |
2008-12-3
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pubmed:abstractText |
The transcription factor c-Myc is essential for cellular proliferation and is one of the most frequently activated oncogenes, but the molecular mechanism mediating its critical role in transformation is unclear. Like c-Myc, multifunctional nucleophosmin (NPM) is tightly regulated during proliferation and is overexpressed in several different types of cancer. Overexpression of NPM enhances proliferation and oncogene-mediated transformation, but the mechanism mediating these effects is unknown. We examined whether NPM stimulates proliferation and transformation by affecting c-Myc. Here, we show that NPM is essential for the activities of oncogenic c-Myc and that overexpressed NPM dramatically stimulates c-Myc-induced hyperproliferation and transformation. Endogenous and exogenous NPM directly interact with c-Myc and regulate the expression of endogenous c-Myc target genes at the promoter. Therefore, NPM is a key cofactor for the transforming activity of c-Myc and the interaction with c-Myc may mediate the enhancement of proliferation and transformation induced by NPM overexppression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-10360173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-10378696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-11282029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-11584300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-11604407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-11756229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-11885563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-12080348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-12665552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-14563837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-15361884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-1555236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-15655352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-15684379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-15723054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-15964625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16007073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16169462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16199867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16724113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16794633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16855788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16935524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16968893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-16984370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-17277230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19033198-2662015
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18794-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19033198-ADP-Ribosylation Factors,
pubmed-meshheading:19033198-Animals,
pubmed-meshheading:19033198-Cell Proliferation,
pubmed-meshheading:19033198-Cell Transformation, Neoplastic,
pubmed-meshheading:19033198-Cells, Cultured,
pubmed-meshheading:19033198-Fibroblasts,
pubmed-meshheading:19033198-Mice,
pubmed-meshheading:19033198-Mice, Knockout,
pubmed-meshheading:19033198-Nuclear Proteins,
pubmed-meshheading:19033198-Protein Structure, Tertiary,
pubmed-meshheading:19033198-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:19033198-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:19033198-Recombinant Fusion Proteins,
pubmed-meshheading:19033198-Transcription, Genetic,
pubmed-meshheading:19033198-Tumor Suppressor Protein p53
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pubmed:year |
2008
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pubmed:articleTitle |
Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.
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pubmed:affiliation |
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-2175, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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