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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-8
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pubmed:abstractText |
Asthma is a disease characterized by variable and reversible airway obstruction and is associated with airway inflammation, airway remodelling (including goblet cell hyperplasia, increased collagen deposition and increased smooth muscle mass) and increased airway responsiveness. It is believed that airway inflammation plays a critical role in the development of airway remodelling, with IL-13 and TGF-beta1 pathways being strongly associated with the disease progression. Mouse models of asthma are capable of recapitulating some components of asthma and have been used to look at both IL-13 and TGF-beta1 pathways, which use STAT6 and SMAD2 signalling molecules, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1365-2222
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-58
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pubmed:meshHeading |
pubmed-meshheading:19032363-Allergens,
pubmed-meshheading:19032363-Animals,
pubmed-meshheading:19032363-Asthma,
pubmed-meshheading:19032363-Bronchial Hyperreactivity,
pubmed-meshheading:19032363-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19032363-Disease Models, Animal,
pubmed-meshheading:19032363-Female,
pubmed-meshheading:19032363-Humans,
pubmed-meshheading:19032363-Interleukin-13,
pubmed-meshheading:19032363-Mice,
pubmed-meshheading:19032363-Mice, Inbred BALB C,
pubmed-meshheading:19032363-Mice, Inbred C57BL,
pubmed-meshheading:19032363-Mice, Knockout,
pubmed-meshheading:19032363-Mice, Transgenic,
pubmed-meshheading:19032363-Ovalbumin,
pubmed-meshheading:19032363-STAT6 Transcription Factor,
pubmed-meshheading:19032363-Smad2 Protein,
pubmed-meshheading:19032363-Species Specificity,
pubmed-meshheading:19032363-Transforming Growth Factor beta1
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pubmed:year |
2009
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pubmed:articleTitle |
Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study.
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pubmed:affiliation |
Firestone Institute for Respiratory Health, St Joseph's Hospital, McMaster University, Hamilton, ON, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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