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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-11-26
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pubmed:abstractText |
Cytomegalovirus (CMV) infection is the most common viral complication after solid organ transplantation (SOT). Whilst current immunosuppression is known to impair antiviral-specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by immunosuppressive therapy remains to be determined. To address this, we compared the genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that the absence of the HLA-C ligand for inhibitory KIR and the presence of activating KIR genes in the recipients were both associated with a lower rate of CMV infection after transplantation. In a cohort of 17 recipients with acute CMV infection, NK cells were phenotyped over a period of time after diagnosis by their expression profile of C-type lectin receptors and capacity to secrete IFN-gamma. The increased expression of the activating C-type lectin receptors NKG2C and NKG2D was paralleled by the decreased IFN-gamma secretion during the early phase of CMV infection. In conclusion, our findings suggest that KIR/HLA genotype and expression of NKG2C and NKG2D might play a significant role in regulating NK cell function and anti-CMV immunity after kidney transplantation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/KLRC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1600-6143
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pubmed:author |
pubmed-author:BandelierCC,
pubmed-author:BernesJJ,
pubmed-author:BuhlerLL,
pubmed-author:Ferrari-LacrazSS,
pubmed-author:HadayaKK,
pubmed-author:JendlySS,
pubmed-author:KaiserLL,
pubmed-author:MartinP YPY,
pubmed-author:SeebachJ DJD,
pubmed-author:TiercyJ MJM,
pubmed-author:VillardJJ,
pubmed-author:de RhamCC
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2674-83
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pubmed:meshHeading |
pubmed-meshheading:19032228-Adult,
pubmed-meshheading:19032228-Cytomegalovirus,
pubmed-meshheading:19032228-Cytomegalovirus Infections,
pubmed-meshheading:19032228-Female,
pubmed-meshheading:19032228-Genotype,
pubmed-meshheading:19032228-HLA-C Antigens,
pubmed-meshheading:19032228-Humans,
pubmed-meshheading:19032228-Interferon-gamma,
pubmed-meshheading:19032228-Kidney Transplantation,
pubmed-meshheading:19032228-Killer Cells, Natural,
pubmed-meshheading:19032228-Lectins, C-Type,
pubmed-meshheading:19032228-Ligands,
pubmed-meshheading:19032228-Male,
pubmed-meshheading:19032228-Middle Aged,
pubmed-meshheading:19032228-NK Cell Lectin-Like Receptor Subfamily C,
pubmed-meshheading:19032228-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:19032228-Postoperative Complications,
pubmed-meshheading:19032228-Receptors, KIR,
pubmed-meshheading:19032228-Receptors, Natural Killer Cell,
pubmed-meshheading:19032228-Retrospective Studies,
pubmed-meshheading:19032228-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.
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pubmed:affiliation |
Service of Nephrology, Geneva University Hospital and Medical School, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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