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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1991-6-19
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pubmed:abstractText |
Iron-responsive elements (IREs) are regulatory RNA elements which serve as specific binding sites for the IRE-binding protein (IRE-BP). Interaction between IREs and IRE-BP induces repression of ferritin mRNA translation and transferrin receptor mRNA stabilization. We describe the identification of extensive amino acid sequence homology between IRE-BP and two known isomerases, aconitase and isopropylmalate (IPM) isomerase. We discuss the implications of this observation with regard to structure/function relationships of IRE-BP. The structural conservation between a regulatory RNA-binding protein and two enzymes involved in intermediary metabolism provides a surprising example of the functional flexibility in biological structures.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-14087357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-182062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-1972545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2156853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2172968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2190189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2207752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2303429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2314277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2598939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2601708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2683086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2693214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2711187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2720460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2726740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2771641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-2798408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-3037088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-3266604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1903202-6323436
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1739-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1903202-Aconitate Hydratase,
pubmed-meshheading:1903202-Amino Acid Sequence,
pubmed-meshheading:1903202-Animals,
pubmed-meshheading:1903202-Carrier Proteins,
pubmed-meshheading:1903202-Humans,
pubmed-meshheading:1903202-Iron-Regulatory Proteins,
pubmed-meshheading:1903202-Isomerases,
pubmed-meshheading:1903202-Molecular Sequence Data,
pubmed-meshheading:1903202-RNA, Messenger,
pubmed-meshheading:1903202-RNA-Binding Proteins,
pubmed-meshheading:1903202-Sequence Alignment,
pubmed-meshheading:1903202-Sequence Homology, Nucleic Acid
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pubmed:year |
1991
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pubmed:articleTitle |
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase.
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pubmed:affiliation |
European Molecular Biology Laboratory, Heidelberg, FRG.
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pubmed:publicationType |
Journal Article
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