Linked Life Data

19031246

Source:http://linkedlifedata.com/resource/pubmed/id/19031246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11-12
pubmed:dateCreated
2008-11-25
pubmed:abstractText
Weisiensin B, a new ent-kaurane diterpenoid, was isolated from traditional Chinese herb Rabdosia weisiensis C.Y. Wu. In this study, cytotoxicity of weisiensin B was tested on four different tumor cell lines and the effect of growth inhibition and apoptosis in BEL-7402 cell line were investigated in vitro. The results indicated that weisiensin B had significant antiproliferation activity on the four cell lines. Further study on BEL-7402 cells involving Hoechst 33258 stain and DNA fragmentation assay revealed the characteristic apoptotic features of nuclear and DNA ladder formation. Flow cytometric (FCM) analysis with propidium iodide (PI) staining demonstrated that BEL-7402 cells treated with weisiensin B were arrested in G(2)/M phase. The results demonstrated that a significant fraction of weisiensin B-treated cells died by an apoptotic pathway in BEL-7402 cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1028-6020
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1055-62
pubmed:dateRevised
2009-7-21
pubmed:meshHeading
pubmed:articleTitle
Cytotoxicity and apoptosis induction of weisiensin B isolated from Rabdosia weisiensis C.Y. Wu in human hepatoma cells.
pubmed:affiliation
College of Life Sciences, Northwest Normal University, Lanzhou, China. dinglan@nwnu.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't