|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-12-23
|
|
pubmed:abstractText |
The inhibitory effects of exogenous melatonin (MEL) on colon oncogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) rat model. Male F344 rats initiated with a single intraperitoneal injection of AOM (20mg/kg bw) were promoted by 1% (w/v) DSS in drinking water for 7 days. They were then given 0.4, 2 or 10ppm MEL in drinking water for 17 weeks. At week 20, the development of colonic adenocarcinoma was significantly inhibited by the administration with MEL dose-dependently. MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies. These results may indicate the beneficial effects of MEL on colitis-related colon carcinogenesis and a potential application for inhibiting colorectal cancer development in the inflamed colon.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Azoxymethane,
http://linkedlifedata.com/resource/pubmed/chemical/Dextran Sulfate,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Melatonin,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1872-7786
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
27
|
|
pubmed:volume |
177
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
128-36
|
|
pubmed:meshHeading |
pubmed-meshheading:19028472-Adenocarcinoma,
pubmed-meshheading:19028472-Animals,
pubmed-meshheading:19028472-Antineoplastic Agents,
pubmed-meshheading:19028472-Apoptosis,
pubmed-meshheading:19028472-Azoxymethane,
pubmed-meshheading:19028472-Colon,
pubmed-meshheading:19028472-Colonic Neoplasms,
pubmed-meshheading:19028472-Dextran Sulfate,
pubmed-meshheading:19028472-Dose-Response Relationship, Drug,
pubmed-meshheading:19028472-Drinking,
pubmed-meshheading:19028472-Immunohistochemistry,
pubmed-meshheading:19028472-Injections, Intraperitoneal,
pubmed-meshheading:19028472-Interleukin-1beta,
pubmed-meshheading:19028472-Intestinal Mucosa,
pubmed-meshheading:19028472-Male,
pubmed-meshheading:19028472-Melatonin,
pubmed-meshheading:19028472-Mitotic Index,
pubmed-meshheading:19028472-NF-kappa B,
pubmed-meshheading:19028472-Rats,
pubmed-meshheading:19028472-Rats, Inbred F344,
pubmed-meshheading:19028472-STAT3 Transcription Factor,
pubmed-meshheading:19028472-Tumor Markers, Biological,
pubmed-meshheading:19028472-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
|
|
pubmed:affiliation |
Department of Oncologic Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. takutt@kanazawa-med.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
