Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-22
pubmed:abstractText
The bradykinin B2 receptor (B2R) mediates many physiological processes such as hypotension, inflammation and blood-vessel permeability. Hypoxia/reoxygenation (H/R) induces neuronal cell apoptosis. It was found that B2R expression was enhanced in primary cultured cortical neurons after H/R treatment. Addition of bradykinin (BK) alleviated the neuronal damage from H/R. This protective effect of BK was inhibited by the B2R antagonist, HOE140, and the ERK1/2 antagonist, PD98059. The phosphorylation of ERK1/2 was increased under H/R, and the addition of BK enhanced this effect. These results indicate that B2R plays an important role in protecting neurons from damage induced by H/R and this effect may function through the ERK1/2 pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
450
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19027830-Animals, pubmed-meshheading:19027830-Apoptosis, pubmed-meshheading:19027830-Bradykinin, pubmed-meshheading:19027830-Cell Hypoxia, pubmed-meshheading:19027830-Cells, Cultured, pubmed-meshheading:19027830-Culture Media, pubmed-meshheading:19027830-Flavonoids, pubmed-meshheading:19027830-MAP Kinase Signaling System, pubmed-meshheading:19027830-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:19027830-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:19027830-Neurons, pubmed-meshheading:19027830-Oxygen, pubmed-meshheading:19027830-Phosphorylation, pubmed-meshheading:19027830-Protein Kinase Inhibitors, pubmed-meshheading:19027830-Rats, pubmed-meshheading:19027830-Rats, Sprague-Dawley, pubmed-meshheading:19027830-Receptor, Bradykinin B2, pubmed-meshheading:19027830-Reperfusion Injury
pubmed:year
2009
pubmed:articleTitle
The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway.
pubmed:affiliation
Department of neurology, Huashan Hospital, Fudan University, Shanghai 200040,China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't