rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-22
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pubmed:abstractText |
The bradykinin B2 receptor (B2R) mediates many physiological processes such as hypotension, inflammation and blood-vessel permeability. Hypoxia/reoxygenation (H/R) induces neuronal cell apoptosis. It was found that B2R expression was enhanced in primary cultured cortical neurons after H/R treatment. Addition of bradykinin (BK) alleviated the neuronal damage from H/R. This protective effect of BK was inhibited by the B2R antagonist, HOE140, and the ERK1/2 antagonist, PD98059. The phosphorylation of ERK1/2 was increased under H/R, and the addition of BK enhanced this effect. These results indicate that B2R plays an important role in protecting neurons from damage induced by H/R and this effect may function through the ERK1/2 pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Bradykinin B2,
http://linkedlifedata.com/resource/pubmed/chemical/icatibant
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
450
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
40-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19027830-Animals,
pubmed-meshheading:19027830-Apoptosis,
pubmed-meshheading:19027830-Bradykinin,
pubmed-meshheading:19027830-Cell Hypoxia,
pubmed-meshheading:19027830-Cells, Cultured,
pubmed-meshheading:19027830-Culture Media,
pubmed-meshheading:19027830-Flavonoids,
pubmed-meshheading:19027830-MAP Kinase Signaling System,
pubmed-meshheading:19027830-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19027830-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19027830-Neurons,
pubmed-meshheading:19027830-Oxygen,
pubmed-meshheading:19027830-Phosphorylation,
pubmed-meshheading:19027830-Protein Kinase Inhibitors,
pubmed-meshheading:19027830-Rats,
pubmed-meshheading:19027830-Rats, Sprague-Dawley,
pubmed-meshheading:19027830-Receptor, Bradykinin B2,
pubmed-meshheading:19027830-Reperfusion Injury
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pubmed:year |
2009
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pubmed:articleTitle |
The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway.
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pubmed:affiliation |
Department of neurology, Huashan Hospital, Fudan University, Shanghai 200040,China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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