| pubmed-article:19026986 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19026986 | lifeskim:mentions | umls-concept:C1333572 | lld:lifeskim |
| pubmed-article:19026986 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:19026986 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:19026986 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19026986 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19026986 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19026986 | pubmed:dateCreated | 2008-12-8 | lld:pubmed |
| pubmed-article:19026986 | pubmed:abstractText | Obesity is associated with a low-grade inflammation in adipose tissue resulting from increased production of pro-inflammatory cytokines and which can subsequently contribute to the development of insulin resistance. However, the mechanisms underlying the transcriptional regulation of pro-inflammatory genes are still unclear. Here we show that tumor necrosis factor (TNF)-alpha treatment attenuated Akt-dependent phosphorylation of Foxo1 and enhanced transcriptional activity of Foxo1. We found that Foxo1 increased the expression of CCAAT/enhancer binding protein (C/EBPbeta, a positive regulator of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-6 genes, through directly binding to its promoter. Furthermore, knockdown of Foxo1 as well as C/EBPbeta inhibits TNF-alpha-induced expression of MCP-1 and IL-6 in 3T3-L1 adipocytes. These findings suggest that activation of Foxo1 triggered by TNF-alpha up-regulates the expression of C/EBPbeta in 3T3-L1 adipocytes, thereby leading to an increased production of pro-inflammatory cytokines, MCP-1 and IL-6. | lld:pubmed |
| pubmed-article:19026986 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19026986 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026986 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19026986 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19026986 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19026986 | pubmed:author | pubmed-author:LuxWW | lld:pubmed |
| pubmed-article:19026986 | pubmed:author | pubmed-author:DaitokuHiroak... | lld:pubmed |
| pubmed-article:19026986 | pubmed:author | pubmed-author:FukamizuAkiyo... | lld:pubmed |
| pubmed-article:19026986 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19026986 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:19026986 | pubmed:volume | 378 | lld:pubmed |
| pubmed-article:19026986 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19026986 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19026986 | pubmed:pagination | 290-5 | lld:pubmed |
| pubmed-article:19026986 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:19026986 | pubmed:meshHeading | pubmed-meshheading:19026986... | lld:pubmed |
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| pubmed-article:19026986 | pubmed:meshHeading | pubmed-meshheading:19026986... | lld:pubmed |
| pubmed-article:19026986 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19026986 | pubmed:articleTitle | Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes. | lld:pubmed |
| pubmed-article:19026986 | pubmed:affiliation | Center for Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan. | lld:pubmed |
| pubmed-article:19026986 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19026986 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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