| pubmed-article:19026632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19026632 | lifeskim:mentions | umls-concept:C0752326 | lld:lifeskim |
| pubmed-article:19026632 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:19026632 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:19026632 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19026632 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19026632 | pubmed:dateCreated | 2008-12-16 | lld:pubmed |
| pubmed-article:19026632 | pubmed:abstractText | The preventative effects of the ethanol extracts of Ganoderma lucidum against the ovariectomized (Ovx)-induced deterioration of bone density in 11-week-old female Sprague Dawley (SD) rats were investigated. The results showed that the G. lucidum-treated Ovx rats showed improved bone density compared with the Ovx rats. We studied the effects of G. lucidum on osteoclastic differentiation using bone marrow cells and RAW 264 cell D-clone (RAW-D). Differentiation, in response to receptor activator of NF-kappaB ligand (RANKL) and a tumor necrosis factor alpha (TNF-alpha), was inhibited by the ethanol extracts of G. lucidum and ganoderic acid DM which was isolated as one of the active compounds by bioassay-guided fractionation. Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). This suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion. | lld:pubmed |
| pubmed-article:19026632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19026632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19026632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19026632 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19026632 | pubmed:issn | 1879-0712 | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:LeeL FLF | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:SatoMasaoM | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:ShimizuKuniyo... | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:KondoRyuichir... | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:KukitaAkikoA | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:KukitaToshioT | lld:pubmed |
| pubmed-article:19026632 | pubmed:author | pubmed-author:MiyamotoIchik... | lld:pubmed |
| pubmed-article:19026632 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19026632 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:19026632 | pubmed:volume | 602 | lld:pubmed |
| pubmed-article:19026632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19026632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19026632 | pubmed:pagination | 1-7 | lld:pubmed |
| pubmed-article:19026632 | pubmed:meshHeading | pubmed-meshheading:19026632... | lld:pubmed |
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| pubmed-article:19026632 | pubmed:meshHeading | pubmed-meshheading:19026632... | lld:pubmed |
| pubmed-article:19026632 | pubmed:meshHeading | pubmed-meshheading:19026632... | lld:pubmed |
| pubmed-article:19026632 | pubmed:meshHeading | pubmed-meshheading:19026632... | lld:pubmed |
| pubmed-article:19026632 | pubmed:meshHeading | pubmed-meshheading:19026632... | lld:pubmed |
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| pubmed-article:19026632 | pubmed:meshHeading | pubmed-meshheading:19026632... | lld:pubmed |
| pubmed-article:19026632 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19026632 | pubmed:articleTitle | Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. | lld:pubmed |
| pubmed-article:19026632 | pubmed:affiliation | Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan. | lld:pubmed |
| pubmed-article:19026632 | pubmed:publicationType | Journal Article | lld:pubmed |
