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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
The preventative effects of the ethanol extracts of Ganoderma lucidum against the ovariectomized (Ovx)-induced deterioration of bone density in 11-week-old female Sprague Dawley (SD) rats were investigated. The results showed that the G. lucidum-treated Ovx rats showed improved bone density compared with the Ovx rats. We studied the effects of G. lucidum on osteoclastic differentiation using bone marrow cells and RAW 264 cell D-clone (RAW-D). Differentiation, in response to receptor activator of NF-kappaB ligand (RANKL) and a tumor necrosis factor alpha (TNF-alpha), was inhibited by the ethanol extracts of G. lucidum and ganoderic acid DM which was isolated as one of the active compounds by bioassay-guided fractionation. Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). This suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1879-0712
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
602
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-7
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pubmed:meshHeading |
pubmed-meshheading:19026632-Animals,
pubmed-meshheading:19026632-Bone Density,
pubmed-meshheading:19026632-Cell Differentiation,
pubmed-meshheading:19026632-Cell Fusion,
pubmed-meshheading:19026632-Dendritic Cells,
pubmed-meshheading:19026632-Female,
pubmed-meshheading:19026632-Gene Expression Regulation,
pubmed-meshheading:19026632-Male,
pubmed-meshheading:19026632-Membrane Proteins,
pubmed-meshheading:19026632-NFATC Transcription Factors,
pubmed-meshheading:19026632-Osteoclasts,
pubmed-meshheading:19026632-Osteogenesis,
pubmed-meshheading:19026632-Ovariectomy,
pubmed-meshheading:19026632-Plant Extracts,
pubmed-meshheading:19026632-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:19026632-RANK Ligand,
pubmed-meshheading:19026632-Rats,
pubmed-meshheading:19026632-Rats, Sprague-Dawley,
pubmed-meshheading:19026632-Reishi,
pubmed-meshheading:19026632-Triterpenes,
pubmed-meshheading:19026632-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.
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pubmed:affiliation |
Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
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pubmed:publicationType |
Journal Article
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