Linked Life Data

19025332

Source:http://linkedlifedata.com/resource/pubmed/id/19025332

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-11-25
pubmed:abstractText
Liverpool John Moores University and FRAME recently conducted a research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with the REACH system. This report focuses on how to maximise the use of alternative methods (both in vitro and in silico) for skin corrosion and irritation testing within a tiered testing strategy. It considers the latest developments in in vitro testing, with particular reference to the reconstituted skin models which have now been now been successfully validated and independently endorsed as suitable for both skin corrosivity and irritancy testing within the EU.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0261-1929
pubmed:author
pubmed:copyrightInfo
2008 FRAME.
pubmed:issnType
Print
pubmed:volume
36 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-74
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation.
pubmed:affiliation
FRAME, Nottingham, UK. frame@frame.org.uk
pubmed:publicationType
Journal Article