Linked Life Data

19025122

Source:http://linkedlifedata.com/resource/pubmed/id/19025122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-11-25
pubmed:abstractText
The complement cascade is a phylogenetically ancient part of our immune system and is critical to an organism's ability to ward off infection. Interest in a possible role for the complement system in the development of ethanol-induced liver injury was inspired by the large body of data implicating the complement system in the development of acute and chronic inflammatory responses to bacteria/bacterial products, as well as in response to cell injury, both hallmarks of ethanol-induced liver injury. Recent investigations have demonstrated that complement is involved in the pathogenesis of ethanol-induced liver injury. Here we review the available data on the contribution of complement to ethanol-induced liver injury and then discuss the potential mechanisms by which the essential roles of complement in protecting the host from infection and facilitating wound healing may contribute to and/or protect from the pathogenesis of alcohol-induced liver injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
632
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-86
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Role of complement in ethanol-induced liver injury.
pubmed:affiliation
Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural