Linked Life Data

19025005

Source:http://linkedlifedata.com/resource/pubmed/id/19025005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-11-25
pubmed:abstractText
Lead (Pb) is a neurotoxic heavy metal and children in the developmental stage are particularly susceptible to toxic effects of lead exposure. The brain is the key organ involved in interpreting and responding to potential stressors. Epidemiological investigations have established the relationship between chronic lead exposure and cognitive impairments in young children. Excessive production of radical species plays an important role in neuronal pathology resulting from excitotoxic insults, therefore one plausible neuroprotective mechanism of bioflavonoids is partly relevant to their metal chelating and antioxidant properties. Centella asiatica (CA) is a tropical medicinal plant enriched with bioflavonoids and triterpenes and selenium, reported to rejuvenate the cells and promote physical and mental health. Bioflavonoids are claimed to be exert antimutagenic, neurotrophic and xenobiotics ameliorating and membrane molecular stabilizing effects. The objective of the present work is to study the protective antioxidant effect of pretreatment of CA extract (CAE) on lead acetate induced changes in oxidative biomarkers in the central nervous system (CNS) of mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0300-5283
pubmed:author
pubmed:issnType
Print
pubmed:volume
63 Suppl A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Protective antioxidant effect of Centella asiatica bioflavonoids on lead acetate induced neurotoxicity.
pubmed:affiliation
Department of Human Biology, International Medical University, Kuala Lumpur, Malaysia.
pubmed:publicationType
Journal Article