| pubmed-article:1902287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0004781 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0085196 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1902287 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1902287 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:1902287 | pubmed:dateCreated | 1991-5-29 | lld:pubmed |
| pubmed-article:1902287 | pubmed:abstractText | L-DOPA stimulated the K(+)-induced [3H]GABA (gamma-aminobutyric acid) release from slices of substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen isolated from the ipsilateral side of 6-hydroxydopamine-lesioned rats, but the release from ipsilateral subthalamic slices was not affected. In substantia nigra, L-DOPA stimulation (EC50 = 1 microM) of [3H]GABA release was dose-dependently blocked (IC50 = 0.1 microM for the stimulation caused by 10 microM L-DOPA) by the D1 antagonist SCH 23390, but was not affected by (-)-sulpiride, a D2 antagonist. SCH 23390 also blocked the stimulation in the other nuclei. The DOPA decarboxylase inhibitor NSD-1015 (500 microM) did not prevent the stimulation induced by L-DOPA in all of the studied nuclei. The results suggest that L-DOPA is able to activate D1 receptors located on the terminals of striatal projections via the dopamine formed by a decarboxylation mediated by an NSD-1015-resistant enzyme. Activation of the presynaptic D1 receptors results in stimulation of GABA release. | lld:pubmed |
| pubmed-article:1902287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1902287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1902287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1902287 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1902287 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:1902287 | pubmed:author | pubmed-author:AcevesJJ | lld:pubmed |
| pubmed-article:1902287 | pubmed:author | pubmed-author:HernandezSS | lld:pubmed |
| pubmed-article:1902287 | pubmed:author | pubmed-author:SierraAA | lld:pubmed |
| pubmed-article:1902287 | pubmed:author | pubmed-author:FloranBB | lld:pubmed |
| pubmed-article:1902287 | pubmed:author | pubmed-author:Martinez-Fong... | lld:pubmed |
| pubmed-article:1902287 | pubmed:author | pubmed-author:MariscalSS | lld:pubmed |
| pubmed-article:1902287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1902287 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:1902287 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:1902287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1902287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1902287 | pubmed:pagination | 223-6 | lld:pubmed |
| pubmed-article:1902287 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1902287 | pubmed:meshHeading | pubmed-meshheading:1902287-... | lld:pubmed |
| pubmed-article:1902287 | pubmed:meshHeading | pubmed-meshheading:1902287-... | lld:pubmed |
| pubmed-article:1902287 | pubmed:meshHeading | pubmed-meshheading:1902287-... | lld:pubmed |
| pubmed-article:1902287 | pubmed:meshHeading | pubmed-meshheading:1902287-... | lld:pubmed |
| pubmed-article:1902287 | pubmed:meshHeading | pubmed-meshheading:1902287-... | lld:pubmed |
| pubmed-article:1902287 | pubmed:meshHeading | pubmed-meshheading:1902287-... | lld:pubmed |
| pubmed-article:1902287 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1902287 | pubmed:articleTitle | L-dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats. | lld:pubmed |
| pubmed-article:1902287 | pubmed:affiliation | Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico D.F. | lld:pubmed |
| pubmed-article:1902287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1902287 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1902287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1902287 | lld:pubmed |
