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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1991-5-29
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pubmed:abstractText |
L-DOPA stimulated the K(+)-induced [3H]GABA (gamma-aminobutyric acid) release from slices of substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen isolated from the ipsilateral side of 6-hydroxydopamine-lesioned rats, but the release from ipsilateral subthalamic slices was not affected. In substantia nigra, L-DOPA stimulation (EC50 = 1 microM) of [3H]GABA release was dose-dependently blocked (IC50 = 0.1 microM for the stimulation caused by 10 microM L-DOPA) by the D1 antagonist SCH 23390, but was not affected by (-)-sulpiride, a D2 antagonist. SCH 23390 also blocked the stimulation in the other nuclei. The DOPA decarboxylase inhibitor NSD-1015 (500 microM) did not prevent the stimulation induced by L-DOPA in all of the studied nuclei. The results suggest that L-DOPA is able to activate D1 receptors located on the terminals of striatal projections via the dopamine formed by a decarboxylation mediated by an NSD-1015-resistant enzyme. Activation of the presynaptic D1 receptors results in stimulation of GABA release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-hydroxybenzylhydrazine,
http://linkedlifedata.com/resource/pubmed/chemical/8-iodo-2,3,4,5-tetrahydro-3-methyl-5...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Dopa Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxydopamines,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Sulpiride,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1902287-Animals,
pubmed-meshheading:1902287-Basal Ganglia,
pubmed-meshheading:1902287-Benzazepines,
pubmed-meshheading:1902287-Brain Chemistry,
pubmed-meshheading:1902287-Dopa Decarboxylase,
pubmed-meshheading:1902287-Dopamine Antagonists,
pubmed-meshheading:1902287-Hydrazines,
pubmed-meshheading:1902287-Hydroxydopamines,
pubmed-meshheading:1902287-Levodopa,
pubmed-meshheading:1902287-Male,
pubmed-meshheading:1902287-Nerve Degeneration,
pubmed-meshheading:1902287-Oxidopamine,
pubmed-meshheading:1902287-Potassium,
pubmed-meshheading:1902287-Rats,
pubmed-meshheading:1902287-Rats, Inbred Strains,
pubmed-meshheading:1902287-Sulpiride,
pubmed-meshheading:1902287-Sympathectomy, Chemical,
pubmed-meshheading:1902287-gamma-Aminobutyric Acid
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pubmed:year |
1991
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pubmed:articleTitle |
L-dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats.
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pubmed:affiliation |
Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico D.F.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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