Source:http://linkedlifedata.com/resource/pubmed/id/19021848
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2009-7-14
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| pubmed:abstractText |
BACKGROUND AND PURPOSE The antiakinetic effect of internal Globus pallidus deep brain stimulation (Gpi-DBS) in Parkinson's disease is not clear and not either how this effect is modulated by L-dopa. METHODS Left Gpi-DBS and/or L-dopa effect was studied with auditory paced right-handed sequential movements on (15)O-butanol positron emission tomography (PET) in five patients. Rest and for conditions during movements (DBS off/L-dopa off; DBS on/L-dopa off; DBS off/L-dopa on; DBS on/L-dopa on) were compared with statistical parametric mapping. RESULTS Gpi-DBS activated the right supplementary motor area/premotor (SMA/PMC), and right insular cortex (IC), and as L-dopa decreased the left sensorimotor cortex (M1/S1) activity. L-dopa increased the left ventrolateral thalamus (VLTH), and decreased the left superior parietal cortex (PC) activity. Gpi-DBS and L-dopa interaction showed right SMA/PMC, IC, and left PC activation, decrease of left VLTH, PMC, and dorsolateral prefrontal cortex (PFC) activity. CONCLUSIONS The improvement of bradykinesia with Gpi-DBS is secondary and contributed to the regress of M1/S1-related rigidity and compensatory SMA/PMC, and IC activation. L-dopa and Gpi-DBS alone each reduces M1/S1 overactivity. Interaction ignores this effect, moreover has akinetic effect in the left VLTH, PMC, and PFC. Motor improvement possibly related to left PC and compensatory right SMA/PMC, and IC activation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1552-6569
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
253-8
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| pubmed:meshHeading |
pubmed-meshheading:19021848-Analysis of Variance,
pubmed-meshheading:19021848-Antiparkinson Agents,
pubmed-meshheading:19021848-Brain,
pubmed-meshheading:19021848-Brain Mapping,
pubmed-meshheading:19021848-Butanols,
pubmed-meshheading:19021848-Deep Brain Stimulation,
pubmed-meshheading:19021848-Disease Progression,
pubmed-meshheading:19021848-Female,
pubmed-meshheading:19021848-Globus Pallidus,
pubmed-meshheading:19021848-Humans,
pubmed-meshheading:19021848-Levodopa,
pubmed-meshheading:19021848-Male,
pubmed-meshheading:19021848-Middle Aged,
pubmed-meshheading:19021848-Motor Activity,
pubmed-meshheading:19021848-Oxygen Radioisotopes,
pubmed-meshheading:19021848-Parkinson Disease,
pubmed-meshheading:19021848-Positron-Emission Tomography,
pubmed-meshheading:19021848-Reaction Time,
pubmed-meshheading:19021848-Task Performance and Analysis
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| pubmed:year |
2009
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| pubmed:articleTitle |
Pallidal deep brain stimulation and L-dopa effect on PET motor activation in advanced Parkinson's disease.
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| pubmed:affiliation |
Department of Neurosurgery, St. John's Hospital, Budapest, Hungary. valalik@parkinson.hu
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| pubmed:publicationType |
Journal Article
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