Linked Life Data

1902176

Source:http://linkedlifedata.com/resource/pubmed/id/1902176

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-5-30
pubmed:abstractText
The cell surface glycoprotein, Pgp-1 (CD44), has been shown to be a marker of murine memory T lymphocytes. When activated, Pgp-1hi memory T cells produce strikingly higher amounts of interferon-gamma (IFN-gamma) than naive Pgp-1lo T cells, yet both subsets make similar levels of interleukin (IL)2. Whereas Pgp-1hi cells represent only 20%-25% of peripheral T cells from most strains, this marker is expressed by the vast majority (greater than 90%) of T cells from autoimmune MRL mice homozygous for the lymphoproliferation (lpr) gene. The massive lymphadenopathy that develops in lpr/lpr mice is composed of both non-mature (CD4-CD8-) T cells as well as a greatly expanded number (up to 300-fold) of mature (CD4+CD8-,CD4-CD8+) T cells. Paralleling the expression of high levels of Pgp-1, we find that compared to normal mouse T cells, the lpr mature T lymphocyte subsets are also very high producers on a per cell basis of IFN-gamma and, for the CD4+ subset, IL 4. Increased concentrations of IFN-gamma and IL 4 produced by large numbers of lpr Pgp-1hi mature T cells could contribute to the autoimmune syndrome in MRL lpr/lpr mice through the effects of these cytokines on augmenting MHC class II expression and production of certain classes of antibodies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1081-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Elevated production of interferon-gamma and interleukin 4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 (CD44) expression.
pubmed:affiliation
Rheumatology and Clinical Immunology Unit, University of Vermont College of Medicine, Burlington 05405.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't