19021422

Source:http://linkedlifedata.com/resource/pubmed/id/19021422

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004927, umls-concept:C0009924, umls-concept:C0016315, umls-concept:C0242485, umls-concept:C0303920, umls-concept:C1515655, umls-concept:C1533691
pubmed:issue	5
pubmed:dateCreated	2008-11-21
pubmed:abstractText	Fluorescence lifetime (FLT) information is complementary to intensity measurement and can be used to improve signal-to-background contrast and provide environment sensing capability. In this study, we evaluate the FLTs of eight near-infrared fluorescent molecular probes in vitro in various solvent mediums and in vivo to establish the correlation between the in vitro and in vivo results. Compared with other mediums, two exponential fittings of the fluorescence decays of dyes dissolved in aqueous albumin solutions accurately predict the range of FLTs observed in vivo. We further demonstrate that the diffusion of a near-infrared (NIR) reporter from a dye-loaded gel can be detected by FLT change in mice as a model of controlled drug release. The mean FLT of the NIR probe increases as the dye diffuses from the highly polar gel interior to the more lipophilic tissue environment. The two-point analysis demonstrates an efficient in vitro method for screening new NIR fluorescent reporters for use as FLT probes in vivo, thereby minimizing the use of animals for FLT screening studies.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 CA109754, http://linkedlifedata.com/resource/pubmed/grant/R01 EB1430, http://linkedlifedata.com/resource/pubmed/grant/R24 CA83060, http://linkedlifedata.com/resource/pubmed/grant/R33 CA100972, http://linkedlifedata.com/resource/pubmed/grant/U01 HL080729-04
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-10420847, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-10637006, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-10878542, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-10946975, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-12033576, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-12124296, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-12579532, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-12822971, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-13809697, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-14640765, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-1519759, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-15295637, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-15524373, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-15568942, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-15606280, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-15616687, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-15895582, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-16834550, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-16995699, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-1741380, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-17573433, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-17711778, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-17711779, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-18087350, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-18092515, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-18250652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-19529654, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-4453017, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-8475182, http://linkedlifedata.com/resource/pubmed/commentcorrection/19021422-9277142
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9605853
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media, http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes
pubmed:status	MEDLINE
pubmed:issn	1083-3668
pubmed:author	pubmed-author:AchilefuSamuelS, pubmed-author:AkersWalter JWJ, pubmed-author:BerezinMikhail YMY, pubmed-author:LeeHyeranH
pubmed:issnType	Print
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	054042
pubmed:dateRevised	2011-5-18
pubmed:meshHeading	pubmed-meshheading:19021422-Algorithms, pubmed-meshheading:19021422-Animals, pubmed-meshheading:19021422-Computer Simulation, pubmed-meshheading:19021422-Contrast Media, pubmed-meshheading:19021422-Fluorescent Dyes, pubmed-meshheading:19021422-Image Enhancement, pubmed-meshheading:19021422-Image Interpretation, Computer-Assisted, pubmed-meshheading:19021422-Male, pubmed-meshheading:19021422-Mice, pubmed-meshheading:19021422-Mice, Nude, pubmed-meshheading:19021422-Microscopy, Fluorescence, Multiphoton, pubmed-meshheading:19021422-Models, Biological, pubmed-meshheading:19021422-Reproducibility of Results, pubmed-meshheading:19021422-Sensitivity and Specificity, pubmed-meshheading:19021422-Spectroscopy, Near-Infrared, pubmed-meshheading:19021422-Whole Body Imaging
pubmed:articleTitle	Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements.
pubmed:affiliation	Washington University School of Medicine, Optical Radiology Laboratory, Department of Radiology, 4525 Scott Avenue, Saint Louis, Missouri 63110, USA.
pubmed:publicationType	Journal Article, Evaluation Studies, Research Support, N.I.H., Extramural