| pubmed-article:19020974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0006434 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C1136310 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C1366562 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0682002 | lld:lifeskim |
| pubmed-article:19020974 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:19020974 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19020974 | pubmed:dateCreated | 2009-2-16 | lld:pubmed |
| pubmed-article:19020974 | pubmed:abstractText | Severe burn shock remains an unsolved clinical problem with urgent needs to explore novel therapeutic approaches. In this study, the in vivo bioactivity of a series of synthetic lactosyl derivatives (oligosaccharides) was assessed on rats with burn shock to elucidate the underlying mechanisms. Administration of An-2 and Gu-4, two lactosyl derivatives with di- and tetravalent beta-D: -galactopyranosyl-(1-4)-beta-D: -glucopyranosyl ligands, significantly prolonged the survival time (P < 0.05 vs. saline), stabilized blood pressure and ameliorated the injuries to vital organs after burn. Flow chamber assay displayed that An-2 and Gu-4 markedly decreased the adhesion of leukocytes to microvessel endothelial cells. Competitive binding assay showed that a CD11b antibody significantly interrupted the interaction of An-2 and Gu-4 with leukocytes from rats with burn shock. With fluorescent microscopy, we further found that the oligosaccharides were selectively bound to leukocytes and with a colocalization of CD11b on the cell membrane. Interestingly, the lectin domain-deficient form of CD11b failed to bind with An-2 and Gu-4. The results suggest that both An-2 and Gu-4 significantly inhibit the adhesion of leukocytes to endothelial cells by binding to CD11b and thereby exert protective effects on severe burn shock. | lld:pubmed |
| pubmed-article:19020974 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19020974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19020974 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19020974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19020974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19020974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19020974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19020974 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19020974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19020974 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19020974 | pubmed:issn | 1573-4986 | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:StamJ WJW | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:ZhaoZhihuiZ | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:ZhangLinL | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:LiuJinghuaJ | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:LiuAihuaA | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:JiangYongY | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:HeJialuJ | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:ZhaoKesenK | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:DengPengP | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:LiZhongjunZ | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:ZhangShuangqu... | lld:pubmed |
| pubmed-article:19020974 | pubmed:author | pubmed-author:GongXiaoweiX | lld:pubmed |
| pubmed-article:19020974 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19020974 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:19020974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19020974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19020974 | pubmed:pagination | 173-88 | lld:pubmed |
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| pubmed-article:19020974 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19020974 | pubmed:articleTitle | Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes. | lld:pubmed |
| pubmed-article:19020974 | pubmed:affiliation | Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, China. | lld:pubmed |
| pubmed-article:19020974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19020974 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
