Linked Life Data

19020911

Source:http://linkedlifedata.com/resource/pubmed/id/19020911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-5-28
pubmed:abstractText
The molecular analysis of methicillin-resistant Staphylococcus aureus (MRSA) from 98 children admitted to the Children's Hospital of Michigan, Detroit, MI, with serious MRSA infections during 2006-2007 was correlated with risk factors, clinical features, and antibiotic susceptibility testing (ABST) results. Isolates were characterized by staphylococcal cassette chromosome (SCC) mec type, the presence of Panton-Valentine leukocidin (PVL) genes, repetitive sequence (rep) polymerase chain reaction (PCR) and pulsed-field gel electrophoresis (PFGE), requirement for surgical intervention, antibiograms, and response to therapy. rep-PCR was more rapid than PFGE typing and correlated well. SCCmec type IV-containing isolates caused 92.8% of all infections, but the demographics and diseases associated with subtypes IVa and IVd differed. Subtype IVa (all PFGE type USA300 and PVL-positive) was identified in 81/93 (87.1%) of patients with community-onset (CO) MRSA, including 21/35 of those with risk factors for health care-associated (HA) infection. All other clones were PVL-negative. Subtype IVd (10 isolates; 9 USA800 and 1 eMRSA15) caused mainly HA-MRSA and no skin and soft tissue infections (SSTI). Seven classic HA-MRSA strains (SCCmec types II [6; 3 USA100 and 3 USA600] and III [1; USA200]) caused HA and hospital-onset (HO) infections. Surgical intervention was required in 68/81 patients infected with USA300 and 8/17 of the others. Most USA300 were susceptible (S) to clindamycin (CD) and patients were treated with CD alone or in combination. The other isolates were generally treated with vancomycin (VA) alone or in combination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1435-4373
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-51
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19020911-Adolescent, pubmed-meshheading:19020911-Anti-Bacterial Agents, pubmed-meshheading:19020911-Bacterial Proteins, pubmed-meshheading:19020911-Bacterial Toxins, pubmed-meshheading:19020911-Bacterial Typing Techniques, pubmed-meshheading:19020911-Child, pubmed-meshheading:19020911-Child, Hospitalized, pubmed-meshheading:19020911-Child, Preschool, pubmed-meshheading:19020911-Cluster Analysis, pubmed-meshheading:19020911-DNA, Bacterial, pubmed-meshheading:19020911-DNA Fingerprinting, pubmed-meshheading:19020911-Exotoxins, pubmed-meshheading:19020911-Female, pubmed-meshheading:19020911-Humans, pubmed-meshheading:19020911-Infant, pubmed-meshheading:19020911-Infant, Newborn, pubmed-meshheading:19020911-Leukocidins, pubmed-meshheading:19020911-Male, pubmed-meshheading:19020911-Methicillin-Resistant Staphylococcus aureus, pubmed-meshheading:19020911-Michigan, pubmed-meshheading:19020911-Microbial Sensitivity Tests, pubmed-meshheading:19020911-Molecular Epidemiology, pubmed-meshheading:19020911-Risk Factors, pubmed-meshheading:19020911-Staphylococcal Infections
pubmed:year
2009
pubmed:articleTitle
Methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized children: correlation of molecular analysis with clinical presentation and antibiotic susceptibility testing (ABST) results.
pubmed:affiliation
Children's Hospital of Michigan, Detroit, 48201, USA. nabdel@dmc.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't