Linked Life Data

19020727

Source:http://linkedlifedata.com/resource/pubmed/id/19020727

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-11-21
pubmed:abstractText
Several lines of evidence support an important role of TGF-beta in the development of colorectal cancer, although the molecular consequences are largely unknown. Soluble transforming growth factor-beta receptor type II (sTbetaRII) is a target of transforming growth factors-beta (TGF-beta) that plays an important role in regulation tumorigenesis, angiogenesis and metastasis of cancer. To elucidate whether overexpression of sTbetaRII could antagonize TGF-beta in colon cancer cells, we constructed a plasmid that contains a cDNA encoding human extracellular region of TbetaRII and transfected this construction into LoVo cells. Surprisingly, in the absence of TGF-beta1, the overexpression of sTbetaRII antagonized TGF-beta-induced cell proliferation, invasion, motility and angiogenesis, and decreased expression of VEGF and MMP-9. Also, sTbetaRII inhibited TGF-beta-induced apoptosis and improved the induction of antitumor immunity. Our data indicated that sTbetaRII attenuated the biological activities of TGF-beta, suggesting that sTbetaRII may have a therapeutic benefit in colorectal cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1021-335X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1449-56
pubmed:meshHeading
pubmed-meshheading:19020727-Antineoplastic Agents, pubmed-meshheading:19020727-Apoptosis, pubmed-meshheading:19020727-Cell Line, Tumor, pubmed-meshheading:19020727-Cell Movement, pubmed-meshheading:19020727-Cell Proliferation, pubmed-meshheading:19020727-Colorectal Neoplasms, pubmed-meshheading:19020727-DNA, Complementary, pubmed-meshheading:19020727-Genetic Vectors, pubmed-meshheading:19020727-Humans, pubmed-meshheading:19020727-Leukocytes, Mononuclear, pubmed-meshheading:19020727-Models, Biological, pubmed-meshheading:19020727-Neoplasm Invasiveness, pubmed-meshheading:19020727-Neovascularization, Pathologic, pubmed-meshheading:19020727-Protein-Serine-Threonine Kinases, pubmed-meshheading:19020727-Receptors, Transforming Growth Factor beta, pubmed-meshheading:19020727-Transforming Growth Factor beta1
pubmed:year
2008
pubmed:articleTitle
Soluble transforming growth factor beta type II receptor attenuates TGF-beta1 activity in human colorectal cancer LoVo cells.
pubmed:affiliation
Department of Oncology, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan 430071, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't