Linked Life Data

19019202

Source:http://linkedlifedata.com/resource/pubmed/id/19019202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-12-2
pubmed:abstractText
A role of serotonin receptors (5-HTRs) in spinal rhythmogenesis has been proposed several years ago based mainly upon data showing that bath-applied 5-HT could elicit locomotor-like rhythms in in vitro isolated spinal cord preparations. Such a role was partially confirmed in vivo after revealing that systemically administered 5-HTR(2) agonists, such as quipazine, could induce some locomotor-like movements (LM) in completely spinal cord-transected (Tx) rodents. However, given the limited binding selectivity of currently available 5-HTR(2) agonists, it has remained difficult to determine clearly if one receptor subtype is specifically associated with LM induction. In situ hybridization, data using tissues from L1-L2 spinal cord segments, where critical locomotor network elements have been identified in mice, revealed greater 5-HTR(2A) mRNA levels in low-thoracic Tx than non-Tx animals. This expression level remained elevated for several days, specifically in the lateral intermediate zone, where peak values were detected at 1 week post-Tx and returned to normal at 3 weeks post-Tx. Behavioral and kinematic analyses revealed quipazine-induced LM in 1-week Tx mice either non-pretreated or pretreated with selective 5-HTR(2B) and/or 5-HTR(2C) antagonists. In contrast, LM completely failed to be induced by quipazine in animals pretreated with selective 5-HTR(2A) antagonists. Altogether, these results provide strong evidence suggesting that 5-HTR(2A) are specifically associated with spinal locomotor network activation and LM generation induced by quipazine in Tx animals. These findings may contribute to design drug treatments aimed at promoting locomotor function recovery in chronic spinal cord-injured patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1460-9568
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2231-42
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19019202-Animals, pubmed-meshheading:19019202-Disease Models, Animal, pubmed-meshheading:19019202-Hindlimb, pubmed-meshheading:19019202-Male, pubmed-meshheading:19019202-Mice, pubmed-meshheading:19019202-Motor Activity, pubmed-meshheading:19019202-Movement, pubmed-meshheading:19019202-Nerve Net, pubmed-meshheading:19019202-Paralysis, pubmed-meshheading:19019202-Quipazine, pubmed-meshheading:19019202-RNA, Messenger, pubmed-meshheading:19019202-Receptor, Serotonin, 5-HT2A, pubmed-meshheading:19019202-Receptor, Serotonin, 5-HT2B, pubmed-meshheading:19019202-Receptor, Serotonin, 5-HT2C, pubmed-meshheading:19019202-Recovery of Function, pubmed-meshheading:19019202-Serotonin, pubmed-meshheading:19019202-Serotonin Antagonists, pubmed-meshheading:19019202-Serotonin Receptor Agonists, pubmed-meshheading:19019202-Spinal Cord, pubmed-meshheading:19019202-Spinal Cord Injuries, pubmed-meshheading:19019202-Synaptic Transmission, pubmed-meshheading:19019202-Thoracic Vertebrae, pubmed-meshheading:19019202-Up-Regulation
pubmed:year
2008
pubmed:articleTitle
Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection.
pubmed:affiliation
Neuroscience Unit, Laval University Medical Center, Quebec City, QC, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't