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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1991-5-21
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pubmed:abstractText |
Aspirin-like drugs (ALD) enhance T cell proliferation by suppressing PG production in monocytes. Normal human T cells do not produce any eicosanoids. Therefore we studied whether ALD would affect purified T cells directly. We found that ALD enhanced the proliferation and IL-2 production of T cells in the absence of monocytes. This effect did not depend on arachidonic acid metabolism as no lipoxygenase products and only nonsuppressive levels of cyclooxygenase products were detected in T cell cultures. Several possible mechanisms of the ALD effect were ruled out including 1) enhanced mitogen binding, 2) induction of activation markers (IL-2R, transferrin receptor, HLA-DR) on the cell surface, 3) down-regulation of suppressor cells. ALD caused a rise in [Ca2+]i which appeared to reflect an influx of Ca2+ from the extracellular milieu and was more pronounced in CD4+ cells. The rise in intracellular levels of Ca2+, that is considered a necessary second messenger for T cell activation, may prime these cells for an enhanced response to mitogens. In addition, ALD increased T cell membrane fluidity but only at higher concentrations than those found to enhance proliferation. The pharmacologic effect of ALD on T cells presents a possible new immunoenhancing potential of these drugs and may have therapeutic use in immunosuppressed individuals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Diclofenac,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Flurbiprofen,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2553-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1901879-Adult,
pubmed-meshheading:1901879-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:1901879-Antigens, CD8,
pubmed-meshheading:1901879-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1901879-Arachidonic Acid,
pubmed-meshheading:1901879-Arachidonic Acids,
pubmed-meshheading:1901879-Calcium,
pubmed-meshheading:1901879-Cell Division,
pubmed-meshheading:1901879-Chromatography, High Pressure Liquid,
pubmed-meshheading:1901879-Diclofenac,
pubmed-meshheading:1901879-Dinoprostone,
pubmed-meshheading:1901879-Drug Synergism,
pubmed-meshheading:1901879-Female,
pubmed-meshheading:1901879-Flow Cytometry,
pubmed-meshheading:1901879-Flurbiprofen,
pubmed-meshheading:1901879-Humans,
pubmed-meshheading:1901879-Indomethacin,
pubmed-meshheading:1901879-Interleukin-2,
pubmed-meshheading:1901879-Lymphocyte Activation,
pubmed-meshheading:1901879-Male,
pubmed-meshheading:1901879-Middle Aged,
pubmed-meshheading:1901879-Phytohemagglutinins,
pubmed-meshheading:1901879-Radioimmunoassay,
pubmed-meshheading:1901879-T-Lymphocytes
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pubmed:year |
1991
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pubmed:articleTitle |
Aspirin-like drugs prime human T cells. Modulation of intracellular calcium concentrations.
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pubmed:affiliation |
Clinical Immunology Section, Audie L. Murphy Memorial Veterans Hospital, San Antonio, TX.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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