rdf:type |
|
lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0018270,
umls-concept:C0036025,
umls-concept:C0036082,
umls-concept:C0038435,
umls-concept:C0040814,
umls-concept:C0040815,
umls-concept:C0178719,
umls-concept:C0205082,
umls-concept:C0300926,
umls-concept:C1314939
|
pubmed:issue |
1
|
pubmed:dateCreated |
2009-1-9
|
pubmed:abstractText |
The role of the acid trehalase encoded by the ATH1 gene in the yeast Saccharomyces cerevisiae is still unclear. In this work, we investigated the regulation of ATH1 transcription and found a clear involvement of the protein kinase Hog1p in the induction of this gene under severe stress conditions, such as high salt. We also detected changes in the acid trehalase activity and trehalose levels, indicating a role of the acid trehalase in intracellular trehalose mobilization. Finally, the growth analysis for different mutants in neutral and acid trehalases after high salt stress implicates acid trehalase activity in saline stress resistance.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1567-1364
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
52-62
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:19016884-Gene Deletion,
pubmed-meshheading:19016884-Gene Expression Profiling,
pubmed-meshheading:19016884-Gene Expression Regulation, Fungal,
pubmed-meshheading:19016884-Mitogen-Activated Protein Kinases,
pubmed-meshheading:19016884-Osmotic Pressure,
pubmed-meshheading:19016884-Saccharomyces cerevisiae,
pubmed-meshheading:19016884-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:19016884-Salinity,
pubmed-meshheading:19016884-Transcription, Genetic,
pubmed-meshheading:19016884-Trehalase,
pubmed-meshheading:19016884-Trehalose
|
pubmed:year |
2009
|
pubmed:articleTitle |
Acid trehalase is involved in intracellular trehalose mobilization during postdiauxic growth and severe saline stress in Saccharomyces cerevisiae.
|
pubmed:affiliation |
Departamento de Bioquímica y Biología Molecular, Universitat de València, Valencia, Spain.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|