Linked Life Data

19016875

Source:http://linkedlifedata.com/resource/pubmed/id/19016875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-12-4
pubmed:abstractText
SilCR, a 17 amino acid putative signaling peptide, was proposed to modulate gene expression in Streptococcus pyogenes. We showed that SilCR added exogenously to an M1 serotype strain lacking the sil locus upregulates the in vitro expression of sagA, siaA, and scpC, genes associated with S. pyogenes pathogenesis. Interestingly, only sagA and siaA were upregulated by SilCR in vivo, whereas the expression of scpC remained unaltered. A previous report indicated that exogenously added SilCR protects mice to some degree from developing necrotic lesions caused by an invasive strain of S. pyogenes. In contrast to this report, we found that SilCR did not reduce lesion formation in a subcutaneous murine model of S. pyogenes infection but rather appeared to delay wound healing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-1097
pubmed:author
pubmed:issnType
Print
pubmed:volume
289
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-25
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Regulation of sagA, siaA and scpC by SilCR, a putative signaling peptide of Streptococcus pyogenes.
pubmed:affiliation
Department of Microbiology, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't