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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-6-22
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pubmed:abstractText |
Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Delta9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P = 0.05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-10615721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-10822338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-11254459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-11526463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-11600486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-12916020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-15126440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-15289816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-15297300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-15960559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-16244653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-16696624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-16741937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-16854249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-16917946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-16968334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-17207127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-17509535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-17942244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-18289089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-18342163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-18345976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-18606954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-18606956,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-8838629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-9634505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-9699687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-9819065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19016476-9819066
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-485X
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pubmed:author |
pubmed-author:AgrawalArpanaA,
pubmed-author:BierutLaura JLJ,
pubmed-author:DickDanielle MDM,
pubmed-author:EdenbergHoward JHJ,
pubmed-author:ForoudTatianaT,
pubmed-author:HesselbrockVictorV,
pubmed-author:HinrichsAnthonyA,
pubmed-author:KramerJohnJ,
pubmed-author:NurnbergerJohn IJIJr,
pubmed-author:SchuckitMarcM,
pubmed-author:WetherillLeahL,
pubmed-author:XueiXiaolingX
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pubmed:copyrightInfo |
2008 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
150B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
736-40
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pubmed:dateRevised |
2011-5-23
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pubmed:meshHeading |
pubmed-meshheading:19016476-Adolescent,
pubmed-meshheading:19016476-Adult,
pubmed-meshheading:19016476-Aged,
pubmed-meshheading:19016476-Aged, 80 and over,
pubmed-meshheading:19016476-Female,
pubmed-meshheading:19016476-Gene Frequency,
pubmed-meshheading:19016476-Genotype,
pubmed-meshheading:19016476-Humans,
pubmed-meshheading:19016476-Linkage Disequilibrium,
pubmed-meshheading:19016476-Male,
pubmed-meshheading:19016476-Marijuana Abuse,
pubmed-meshheading:19016476-Middle Aged,
pubmed-meshheading:19016476-Polymorphism, Single Nucleotide,
pubmed-meshheading:19016476-Receptor, Cannabinoid, CB1,
pubmed-meshheading:19016476-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
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pubmed:affiliation |
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. arpana@wustl.edu
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pubmed:publicationType |
Journal Article,
Multicenter Study,
Research Support, N.I.H., Extramural
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