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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-5-13
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pubmed:abstractText |
Interleukin-1, a mediator of inflammation, or tumor promoting phorbol esters induce transcription of stromelysin, a metalloproteinase that degrades extracellular matrix molecules and that is overexpressed in diseases such as rheumatoid arthritis. Sequences required for induction of transcription of the human stromelysin promoter are contained on a 46 base pair fragment. This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1. Maximal induction requires functional cooperation between the AP-1 sequence and a neighboring upstream regulatory sequence (URS) of the stromelysin promoter which is also necessary but not sufficient. We demonstrate that both the AP-1 sequence and the URS bind phorbol or interleukin-1 induced nuclear proteins. Cooperation of the AP-1 sequence with another sequence present in the stromelysin promoter may be a general mechanism whereby the AP-1 element, which is found in many promoters, achieves a maximal and specific response to various stimuli.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-1695008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2162765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2431284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2504586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2537468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2555163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2605216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2785989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2799385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2824488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-2825772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-3025651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-3034432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-3037355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-3037497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-3141060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1901643-6960240
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1901643-Cells, Cultured,
pubmed-meshheading:1901643-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:1901643-DNA,
pubmed-meshheading:1901643-DNA-Binding Proteins,
pubmed-meshheading:1901643-Humans,
pubmed-meshheading:1901643-Interleukin-1,
pubmed-meshheading:1901643-Matrix Metalloproteinase 3,
pubmed-meshheading:1901643-Metalloendopeptidases,
pubmed-meshheading:1901643-Molecular Sequence Data,
pubmed-meshheading:1901643-Plasmids,
pubmed-meshheading:1901643-Promoter Regions, Genetic,
pubmed-meshheading:1901643-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:1901643-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1901643-Tetradecanoylphorbol Acetate,
pubmed-meshheading:1901643-Trans-Activators,
pubmed-meshheading:1901643-Transcription, Genetic,
pubmed-meshheading:1901643-Transcription Factors,
pubmed-meshheading:1901643-Transfection
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pubmed:year |
1991
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pubmed:articleTitle |
Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1.
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pubmed:affiliation |
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03756.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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