Source:http://linkedlifedata.com/resource/pubmed/id/19016238
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2009-3-11
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pubmed:abstractText |
The hydrogen-deuterium exchange of protonated melatonin and its in vitro oxidation end-products have been examined by liquid chromatography coupled with ion-trap mass spectrometry. Specific H/D scrambling of protons in the C2 and C4 positions of the indole ring during gas-phase fragmentation process was observed for both melatonin and its oxidation products. Collision-induced dissociation spectra showed losses of variably deuterated NH(3), H(2)O and CH(3)CONH(2). In addition, a similar H/D scrambling behaviour was observed for the oxidation products, obtained from the opening of the indole ring by oxidative attack. Fragmentation pathways are proposed and H/D scrambling has been employed as a fingerprint, allowing identification of N(1)-acetyl-5-methoxykynurenin (AMK), N(1)-acetyl-N(2)-formyl-5-methoxykynurenin (AFMK), dehydro-AFMK and hydroxymelatonin as the oxidation products of melatonin in vitro.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Kynuramine,
http://linkedlifedata.com/resource/pubmed/chemical/Melatonin,
http://linkedlifedata.com/resource/pubmed/chemical/N-acetyl-5-methoxy kynurenamine,
http://linkedlifedata.com/resource/pubmed/chemical/N-acetyl-N-formyl-5-methoxykynurenam...,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1096-9888
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2009 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
318-29
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pubmed:meshHeading |
pubmed-meshheading:19016238-Chromatography, High Pressure Liquid,
pubmed-meshheading:19016238-Deuterium Exchange Measurement,
pubmed-meshheading:19016238-Kynuramine,
pubmed-meshheading:19016238-Mass Spectrometry,
pubmed-meshheading:19016238-Melatonin,
pubmed-meshheading:19016238-Models, Molecular,
pubmed-meshheading:19016238-Oxidation-Reduction,
pubmed-meshheading:19016238-Reactive Oxygen Species
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pubmed:year |
2009
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pubmed:articleTitle |
Online H/D exchange liquid chromatography as a support for the mass spectrometric identification of the oxidation products of melatonin.
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pubmed:affiliation |
Laboratoire de Chimie-Physique, CNRS UMR 8601, Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France. fabrice.collin@univ-paris5.fr
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pubmed:publicationType |
Journal Article
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