Linked Life Data

19016238

Source:http://linkedlifedata.com/resource/pubmed/id/19016238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-3-11
pubmed:abstractText
The hydrogen-deuterium exchange of protonated melatonin and its in vitro oxidation end-products have been examined by liquid chromatography coupled with ion-trap mass spectrometry. Specific H/D scrambling of protons in the C2 and C4 positions of the indole ring during gas-phase fragmentation process was observed for both melatonin and its oxidation products. Collision-induced dissociation spectra showed losses of variably deuterated NH(3), H(2)O and CH(3)CONH(2). In addition, a similar H/D scrambling behaviour was observed for the oxidation products, obtained from the opening of the indole ring by oxidative attack. Fragmentation pathways are proposed and H/D scrambling has been employed as a fingerprint, allowing identification of N(1)-acetyl-5-methoxykynurenin (AMK), N(1)-acetyl-N(2)-formyl-5-methoxykynurenin (AFMK), dehydro-AFMK and hydroxymelatonin as the oxidation products of melatonin in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1096-9888
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2009 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-29
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Online H/D exchange liquid chromatography as a support for the mass spectrometric identification of the oxidation products of melatonin.
pubmed:affiliation
Laboratoire de Chimie-Physique, CNRS UMR 8601, Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France. fabrice.collin@univ-paris5.fr
pubmed:publicationType
Journal Article