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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-11-18
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pubmed:abstractText |
The treatment of skin ulcers frequently presents a management challenge. Nonhealing wounds with poor response to conventional wound management therapy represent a significant cause of disability, affecting approximately 1% of the global population. Activated protein C is a serine protease with anticoagulant, angiogenic, and anti-inflammatory properties that has shown efficacy in patients for the treatment of severe sepsis. We report 4 cases of nonhealing lower limb skin ulcers that were treated with activated protein C.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1538-3652
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pubmed:author |
pubmed-author:CooperAlanA,
pubmed-author:FulcherGregG,
pubmed-author:JacksonChrisC,
pubmed-author:LeeMichaelM,
pubmed-author:ManjiK PKP,
pubmed-author:ReidIanI,
pubmed-author:SambrookPhilP,
pubmed-author:SlobedmanEricE,
pubmed-author:TrittonSaraS,
pubmed-author:WhitmontKaleyK,
pubmed-author:XueMeilangM
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pubmed:issnType |
Electronic
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1479-83
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pubmed:meshHeading |
pubmed-meshheading:19015423-Administration, Topical,
pubmed-meshheading:19015423-Aged,
pubmed-meshheading:19015423-Biopsy, Needle,
pubmed-meshheading:19015423-Chronic Disease,
pubmed-meshheading:19015423-Debridement,
pubmed-meshheading:19015423-Dose-Response Relationship, Drug,
pubmed-meshheading:19015423-Drug Administration Schedule,
pubmed-meshheading:19015423-Follow-Up Studies,
pubmed-meshheading:19015423-Humans,
pubmed-meshheading:19015423-Immunohistochemistry,
pubmed-meshheading:19015423-Leg Ulcer,
pubmed-meshheading:19015423-Male,
pubmed-meshheading:19015423-Protein C,
pubmed-meshheading:19015423-Risk Assessment,
pubmed-meshheading:19015423-Sampling Studies,
pubmed-meshheading:19015423-Severity of Illness Index,
pubmed-meshheading:19015423-Skin Care,
pubmed-meshheading:19015423-Treatment Outcome,
pubmed-meshheading:19015423-Wound Healing
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pubmed:year |
2008
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pubmed:articleTitle |
Treatment of chronic leg ulcers with topical activated protein C.
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pubmed:affiliation |
Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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