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pubmed-article:19014884pubmed:abstractTextThe synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a approximately 60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit K(i) values of approximately 10nM.lld:pubmed
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pubmed-article:19014884pubmed:articleTitleSulfonamido-aryl ethers as bradykinin B1 receptor antagonists.lld:pubmed
pubmed-article:19014884pubmed:affiliationPharmacopeia Inc, Princeton, NJ 08543, USA. acole@pcop.comlld:pubmed
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