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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-26
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pubmed:abstractText |
The synthesis and identification of sulfonamido-aryl ethers as potent bradykinin B1 receptor antagonists from a approximately 60,000 member encoded combinatorial library are reported. Two distinct series of compounds exhibiting different structure-activity relationships were identified in a bradykinin B1 whole-cell receptor-binding assay. Specific examples exhibit K(i) values of approximately 10nM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AppellKenneth CKC,
pubmed-author:BaldwinJohn JJJ,
pubmed-author:BevanStuart JSJ,
pubmed-author:BrainChristopher TCT,
pubmed-author:BresciaMarc-RaleighMR,
pubmed-author:ColeAndrew GAG,
pubmed-author:DenholmAlastair AAA,
pubmed-author:DolleRoland ERE,
pubmed-author:DrakeGillian MGM,
pubmed-author:GanjuPamP,
pubmed-author:GstachHubertH,
pubmed-author:HallettAllanA,
pubmed-author:HendersonIanI,
pubmed-author:MacGloinnAislingA,
pubmed-author:McBrydeAndrewA,
pubmed-author:McDonaldEdwardE,
pubmed-author:MetzgerAxelA,
pubmed-author:NunezXimenaX,
pubmed-author:OakleyPaul JPJ,
pubmed-author:PatelViralV,
pubmed-author:QinLan-YingLY,
pubmed-author:RitchieTimothy JTJ,
pubmed-author:SchneiderPeterP,
pubmed-author:WareingJames RJR
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-22
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.
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pubmed:affiliation |
Pharmacopeia Inc, Princeton, NJ 08543, USA. acole@pcop.com
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pubmed:publicationType |
Journal Article
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