Linked Life Data

19013541

Source:http://linkedlifedata.com/resource/pubmed/id/19013541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-12
pubmed:abstractText
This study investigated the effects of ursolic acid on immunoregulation and pancreatic beta-cell function in type 1 diabetes fed a high-fat diet for 4 weeks. Male mice were divided into non-diabetic, diabetic control, and diabetic-ursolic acid (0.05%, w/w) groups, which were fed a high-fat (37% calories from fat). Diabetes was induced by injection of streptozotocin (200 mg/kg B.W., i.p.). Ursolic acid significantly improved blood glucose levels, glucose intolerance, and insulin sensitivity compared to the diabetic group. The plasma insulin and C-peptide concentrations were significantly higher in the diabetic-ursolic acid group than in the diabetic group. Ursolic acid significantly elevated the insulin levels with preservation of insulin staining of beta-cells in the pancreas. In splenocytes, concanavalin (Con) A-induced T-cell proliferation was significantly higher in the diabetic-ursolic acid group compared to the diabetic group, but liposaccharide (LPS)-induced B-cell proliferation did not differ between groups. Ursolic acid enhanced IL-2 and IFN-gamma production in response to Con A stimulation, whereas it inhibited TNF-alpha production in response to LPS stimulation. In this study, neither streptozotocin nor ursolic acid had effects on lymphocyte subsets. These results indicate that ursolic acid exhibits potential anti-diabetic and immunomodulatory properties by increasing insulin levels with preservation of pancreatic beta-cells and modulating blood glucose levels, T-cell proliferation and cytokines production by lymphocytes in type 1 diabetic mice fed a high-fat diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1567-5769
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19013541-Adjuvants, Immunologic, pubmed-meshheading:19013541-Animals, pubmed-meshheading:19013541-Antigens, Surface, pubmed-meshheading:19013541-Blood Glucose, pubmed-meshheading:19013541-C-Peptide, pubmed-meshheading:19013541-Cytokines, pubmed-meshheading:19013541-Diabetes Mellitus, Experimental, pubmed-meshheading:19013541-Diet, pubmed-meshheading:19013541-Dietary Fats, pubmed-meshheading:19013541-Dietary Supplements, pubmed-meshheading:19013541-Glucose Tolerance Test, pubmed-meshheading:19013541-Hyperglycemia, pubmed-meshheading:19013541-Hypoglycemic Agents, pubmed-meshheading:19013541-Immunity, Cellular, pubmed-meshheading:19013541-Immunohistochemistry, pubmed-meshheading:19013541-Insulin, pubmed-meshheading:19013541-Insulin-Secreting Cells, pubmed-meshheading:19013541-Lymphocytes, pubmed-meshheading:19013541-Male, pubmed-meshheading:19013541-Mice, pubmed-meshheading:19013541-Mice, Inbred ICR, pubmed-meshheading:19013541-Pancreas, pubmed-meshheading:19013541-Pancreatic Function Tests, pubmed-meshheading:19013541-Triterpenes
pubmed:year
2009
pubmed:articleTitle
Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet.
pubmed:affiliation
Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540-742, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't