Linked Life Data

1901181

Source:http://linkedlifedata.com/resource/pubmed/id/1901181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-4-29
pubmed:abstractText
A randomized double blind comparison of transdermal nitroglycerin and isosorbide dinitrate tablets was conducted in 100 men with stable angina pectoris. Subjective and objective effects were virtually identical for both regimens (number of angina attacks/nitroglycerin consumption and exercise ECG test variables). The pattern of side effects was also similar for both drugs. A considerable dissociation was observed between subjective effects and effects measured by ergometer test in the individual patient. Lack of both subjective and objective effects--i.e. nitrate tolerance--was observed in approximately one fourth of the patients, and was not prevented by a twelve-hour dosing interval on isosorbide dinitrate nor a six hour transdermal nitroglycerin-free interval. Our data lends credence to the notion that the effects of long-acting nitrates in daily life and the effects measured during stress testing may involve different mechanisms.
pubmed:language
nor
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0029-2001
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-82
pubmed:dateRevised
2008-7-16
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Prolonged action nitrates in stable angina pectoris].
pubmed:affiliation
Medisinsk avdeling, Sentralsykehuset i Akershus, Nordbyhagen.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial