Linked Life Data

19011120

Source:http://linkedlifedata.com/resource/pubmed/id/19011120

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-6
pubmed:abstractText
Trichomonas vaginalis is one of a few eukaryotes that have been found to encode several homologues of flavodiiron proteins (FDPs). Widespread among anaerobic prokaryotes, these proteins are believed to function as oxygen and/or nitric oxide reductases to provide protection against oxidative/nitrosative stresses and host immune responses. One of the T. vaginalis FDP homologues is equipped with a hydrogenosomal targeting sequence and is expressed in the hydrogenosomes, oxygen-sensitive organelles that participate in carbohydrate metabolism and assemble iron-sulfur clusters. The bacterial homologues characterized thus far have been dimers or tetramers; the trichomonad protein is a dimer of identical 45-kDa subunits, each noncovalently binding one flavin mononucleotide. The protein reduces dioxygen to water but is unable to utilize nitric oxide as a substrate, similarly to its closest homologue from another human parasite Giardia intestinalis and related archaebacterial proteins. T. vaginalis FDP is able to accept electrons derived from pyruvate or NADH via ferredoxin and is proposed to play a role in the protection of hydrogenosomes against oxygen.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-11062560, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-11751865, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-12101220, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-12546782, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-12627946, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-14110802, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-14630923, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15004700, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15226492, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15340796, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15504736, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15510149, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15518829, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15577909, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15729342, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15736966, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-15904985, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16030248, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16040811, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16100392, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16120804, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16304169, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16551352, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-16585735, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-17218520, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-17480207, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-17542912, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-18077462, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-18433621, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-2213652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-3016535, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-3090435, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-3257811, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-3876951, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-3921658, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-4152312, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-4750424, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-624725, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-7563125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-7581334, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-8126416, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-8375383, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-8503894, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-8663034, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-9027755, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-9114057, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-9218791, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-9278402, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-9564565, http://linkedlifedata.com/resource/pubmed/commentcorrection/19011120-9660187
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1535-9786
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-55
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Flavodiiron protein from Trichomonas vaginalis hydrogenosomes: the terminal oxygen reductase.
pubmed:affiliation
Department of Parasitology, Charles University, Vinicná, Prague, Czech Republic.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't