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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2008-11-17
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pubmed:abstractText |
Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are associated with sensitivity of lung adenocarcinomas to the EGFR tyrosine kinase inhibitors, gefitinib and erlotinib. Acquired drug resistance is frequently associated with a secondary somatic mutation that leads to the substitution of methionine for threonine at position 790 (T790M). We aimed to identify additional second-site alterations associated with acquired resistance.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-11423618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-12196540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-12204532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-14745431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15118073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15118125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15329413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15374980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15457249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15728811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15737014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-15897464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-16049312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-16281074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-16397024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-16467097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-16775234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-16818686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17020982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17085664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17349577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17463250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17487277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17671201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17726540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17973572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-17974985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-18026190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-18093943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19010870-18227510
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7519-25
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pubmed:dateRevised |
2011-1-21
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pubmed:meshHeading |
pubmed-meshheading:19010870-Adenocarcinoma,
pubmed-meshheading:19010870-Aged,
pubmed-meshheading:19010870-Amino Acid Sequence,
pubmed-meshheading:19010870-Antineoplastic Agents,
pubmed-meshheading:19010870-Base Sequence,
pubmed-meshheading:19010870-Cell Line, Tumor,
pubmed-meshheading:19010870-Drug Resistance, Neoplasm,
pubmed-meshheading:19010870-Female,
pubmed-meshheading:19010870-Humans,
pubmed-meshheading:19010870-Immunoblotting,
pubmed-meshheading:19010870-Lung Neoplasms,
pubmed-meshheading:19010870-Molecular Sequence Data,
pubmed-meshheading:19010870-Mutation,
pubmed-meshheading:19010870-Polymerase Chain Reaction,
pubmed-meshheading:19010870-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19010870-Protein Kinase Inhibitors,
pubmed-meshheading:19010870-Protein Structure, Quaternary,
pubmed-meshheading:19010870-Quinazolines,
pubmed-meshheading:19010870-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19010870-Sequence Alignment
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pubmed:year |
2008
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pubmed:articleTitle |
Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma.
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pubmed:affiliation |
Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article
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