|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2009-1-23
|
|
pubmed:abstractText |
Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report the results of a genome-wide association study performed in a 1000 prospective case series of well-characterized individuals with MS and group-matched controls using the Sentrix HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, we compared allele frequencies for 551 642 SNPs in 978 cases and 883 controls and assessed genotypic influences on susceptibility, age of onset, disease severity, as well as brain lesion load and normalized brain volume from magnetic resonance imaging exams. A multi-analytical strategy identified 242 susceptibility SNPs exceeding established thresholds of significance, including 65 within the MHC locus in chromosome 6p21.3. Independent replication confirms a role for GPC5, a heparan sulfate proteoglycan, in disease risk. Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotype.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1460-2083
|
|
pubmed:author |
pubmed-author:AngelakopoulouAspasiaA,
pubmed-author:BaranziniSergio ESE,
pubmed-author:BarkhofFrederikF,
pubmed-author:CaillierStacy JSJ,
pubmed-author:CreeBruce A CBA,
pubmed-author:GalweyNicholasN,
pubmed-author:GassAchimA,
pubmed-author:GeorgeMichaela FMF,
pubmed-author:GeurtsJeroen J GJJ,
pubmed-author:GibsonRachel ARA,
pubmed-author:GomezRefujiaR,
pubmed-author:GoodinDouglas SDS,
pubmed-author:GreenAri JAJ,
pubmed-author:GuerreroRosaR,
pubmed-author:HallLeslieL,
pubmed-author:HauserStephen LSL,
pubmed-author:JohnsonMichael RMR,
pubmed-author:KapposLudwigL,
pubmed-author:KragtJolijnJ,
pubmed-author:LincolnRobin RRR,
pubmed-author:LindbergRaija L PRL,
pubmed-author:MatthewsPaul MPM,
pubmed-author:MousaviHouriehH,
pubmed-author:NaegelinYvonneY,
pubmed-author:OksenbergJorge RJR,
pubmed-author:OkudaDarin TDT,
pubmed-author:PelletierDanielD,
pubmed-author:PolmanChris HCH,
pubmed-author:PrinjhaRab KRK,
pubmed-author:QualleyPamelaP,
pubmed-author:RadueErnst-WilhelmEW,
pubmed-author:RichardsonJill CJC,
pubmed-author:SombekkeMadeleineM,
pubmed-author:UitdehaagBernard M GBM,
pubmed-author:VrenkenHugoH,
pubmed-author:WangJoanneJ,
pubmed-author:WaubantEmmanuelleE
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
767-78
|
|
pubmed:meshHeading |
pubmed-meshheading:19010793-Adolescent,
pubmed-meshheading:19010793-Adult,
pubmed-meshheading:19010793-Age of Onset,
pubmed-meshheading:19010793-Aged,
pubmed-meshheading:19010793-Case-Control Studies,
pubmed-meshheading:19010793-Child,
pubmed-meshheading:19010793-European Continental Ancestry Group,
pubmed-meshheading:19010793-Female,
pubmed-meshheading:19010793-Genetic Predisposition to Disease,
pubmed-meshheading:19010793-Genome-Wide Association Study,
pubmed-meshheading:19010793-Glypicans,
pubmed-meshheading:19010793-Humans,
pubmed-meshheading:19010793-Male,
pubmed-meshheading:19010793-Middle Aged,
pubmed-meshheading:19010793-Multiple Sclerosis,
pubmed-meshheading:19010793-Phenotype,
pubmed-meshheading:19010793-Polymorphism, Single Nucleotide,
pubmed-meshheading:19010793-Prospective Studies,
pubmed-meshheading:19010793-Young Adult
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
|
pubmed:affiliation |
Department of Neurology, University of California, San Francisco, CA 94143-0435, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
