Linked Life Data

19010675

Source:http://linkedlifedata.com/resource/pubmed/id/19010675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-26
pubmed:abstractText
A series of 9-substituted and 2,9-disubstituted 6-(3-aminophenylamino) purines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 6-(3-aminoanilinyl) purine component was essential for activity. Purine 14 demonstrated significant activity, compared to protein A. These compounds may prove useful for the treatment of autoimmune diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
242-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
2,6,9-Trisubstituted purine derivatives as protein A mimetics for the treatment of autoimmune diseases.
pubmed:affiliation
ProMetic BioSciences Inc, Que, Canada. b.zacharie@prometic.com
pubmed:publicationType
Journal Article