Linked Life Data

19010346

Source:http://linkedlifedata.com/resource/pubmed/id/19010346

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Cerebral ischemia resulting from transient or permanent cerebral artery occlusion leads to neuronal cell death, and eventually causes neurological impairments. Tadalafil (Cialis)is a long-acting phosphodiesterase type-5 (PDE-5) inhibitor used to treat erectile dysfunction. The therapeutic effects of PDE-5 inhibitors on chronic obstructive pulmonary disease, prostate hyperplasia, hypertension, and coronary heart disease have been reported. The present study investigated the effects of tadalafil on short-term memory, cyclic guanosine monophosphate (cGMP) level, apoptotic neuronal cell death, and cell proliferation in the hippocampus following transient global ischemia in gerbils. For this study, a step-down avoidance task, cGMP assay, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, and immunohistochemistry for caspase-3 and 5-bromo-2'-deoxyuridine were performed. The results revealed that ischemic injury increased apoptotic neuronal cell death in the hippocampal CA1 region, impaired short-term memory, and decreased cGMP level. Ischemic injury enhanced cell proliferation in the hippocampal dentate gyrus. Tadalafil treatment improved short-term memory by suppressing ischemia-induced apoptotic neuronal cell death in the hippocampal CA1 region, and decreased cGMP level. Also, tadalafil suppressed the ischemia-induced increase in cell proliferation in the hippocampal dentate gyrus. We showed that tadalafil can overcome ischemia-induced apoptotic neuronal cell death, thus facilitates recovery following ischemic cerebral injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-35
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19010346-Animals, pubmed-meshheading:19010346-Antimetabolites, pubmed-meshheading:19010346-Apoptosis, pubmed-meshheading:19010346-Avoidance Learning, pubmed-meshheading:19010346-Brain Ischemia, pubmed-meshheading:19010346-Bromodeoxyuridine, pubmed-meshheading:19010346-Carbolines, pubmed-meshheading:19010346-Caspase 3, pubmed-meshheading:19010346-Cyclic GMP, pubmed-meshheading:19010346-Dentate Gyrus, pubmed-meshheading:19010346-Gerbillinae, pubmed-meshheading:19010346-Hippocampus, pubmed-meshheading:19010346-Immunohistochemistry, pubmed-meshheading:19010346-In Situ Nick-End Labeling, pubmed-meshheading:19010346-Memory, Short-Term, pubmed-meshheading:19010346-Neurons, pubmed-meshheading:19010346-Phosphodiesterase 5 Inhibitors, pubmed-meshheading:19010346-Phosphodiesterase Inhibitors
pubmed:year
2009
pubmed:articleTitle
Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils.
pubmed:affiliation
Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't