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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-11-17
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pubmed:abstractText |
The T(H)1 and T(H)2 cells were described several years ago. However, this dichotomy has been disrupted by the description of other CD4(+) T cell subsets: the proinflammatory interleukin (IL)-17-producing T cells (T(H)17) and regulatory T cells (Tregs). The latter group inhibits the immune responses driven by T(H)1, T(H)2, and T(H)17 cells. IL-6 is involved in T(H)17 development, down-regulating Treg differentiation. Our hypothesis suggested that an imbalance between T(H)17 and Tregs enhances immune responses among renal transplant patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0041-1345
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2885-8
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pubmed:meshHeading |
pubmed-meshheading:19010136-Adult,
pubmed-meshheading:19010136-Aged,
pubmed-meshheading:19010136-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19010136-Female,
pubmed-meshheading:19010136-Forkhead Transcription Factors,
pubmed-meshheading:19010136-Humans,
pubmed-meshheading:19010136-Interleukin-17,
pubmed-meshheading:19010136-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:19010136-Kidney Failure, Chronic,
pubmed-meshheading:19010136-Kidney Transplantation,
pubmed-meshheading:19010136-Male,
pubmed-meshheading:19010136-Middle Aged,
pubmed-meshheading:19010136-Reoperation,
pubmed-meshheading:19010136-T-Lymphocytes, Regulatory,
pubmed-meshheading:19010136-Th1 Cells,
pubmed-meshheading:19010136-Th2 Cells
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pubmed:year |
2008
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pubmed:articleTitle |
T(H)17 versus Treg cells in renal transplant candidates: effect of a previous transplant.
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pubmed:affiliation |
Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Fundación Marqués de Valdecilla-IFIMAV, Santander, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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