| pubmed-article:19006261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0328767 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C1414449 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C1414450 | lld:lifeskim |
| pubmed-article:19006261 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
| pubmed-article:19006261 | pubmed:dateCreated | 2008-11-13 | lld:pubmed |
| pubmed-article:19006261 | pubmed:abstractText | The prostate cancer HERV-K gag-related NGO-Pr-54 antigen was identified by SEREX analysis using autologous patient serum. NGO-Pr-54 mRNA was observed to be faintly expressed in normal prostate and strongly expressed in a variety of cancers, including ovarian cancer (5/8), prostate cancer (6/9), and leukemia (5/14). A phage plaque assay showed that a strong reaction was constantly observed with clone ZH042 in which the 5' end of NGO-Pr-54 is deleted, suggesting that it contained the sequence coding for the protein product. A TI-35 mAb was produced using a recombinant protein (438 aa) deduced from the sequence of ZH042. Transfection of clone ZH042 into 293T cells resulted in the production of an approximately 50-kDa molecule visualized by Western blotting. Natural production of the molecule was confirmed in a SK-MEL-23 melanoma cell line. An indirect immunofluorescence assay showed that NGO-Pr-54 protein was expressed on the cell surface as well as in the cytoplasm. Cell surface expression was confirmed by flow cytometry using the TI-35 mAb. The antibody response against NGO-Pr-54 was observed in patients with bladder (5.1%), liver (4.1%), lung (3.4%), ovarian (5.6%), and prostate (4.2%) cancer, as well as with malignant melanoma (13.2%). | lld:pubmed |
| pubmed-article:19006261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19006261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19006261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19006261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19006261 | pubmed:issn | 1424-9634 | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:YamashitaTosh... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:UenakaAkikoA | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:NakayamaEiich... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:OldLloyd JLJ | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:ObataYuichiY | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:SaikaTakashiT | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:MorishimaTsun... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:OharaNobuyaN | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:SatoShuichiro... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:MatsushitaHir... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:WadaHisashiH | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:MiyamuraTakak... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:ChayamaKosuke... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:IshidaToshiak... | lld:pubmed |
| pubmed-article:19006261 | pubmed:author | pubmed-author:NakamuraYurik... | lld:pubmed |
| pubmed-article:19006261 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19006261 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:19006261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19006261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19006261 | pubmed:pagination | 15 | lld:pubmed |
| pubmed-article:19006261 | pubmed:dateRevised | 2010-12-15 | lld:pubmed |
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| pubmed-article:19006261 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19006261 | pubmed:articleTitle | Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity. | lld:pubmed |
| pubmed-article:19006261 | pubmed:affiliation | Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. | lld:pubmed |
| pubmed-article:19006261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19006261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19006261 | lld:entrezgene |
| lhgdn:association:53425 | lhgdn:found_in | pubmed-article:19006261 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19006261 | lld:pubmed |
