Linked Life Data

19005466

Source:http://linkedlifedata.com/resource/pubmed/id/19005466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-1-12
pubmed:abstractText
Adult hippocampal neurogenesis is decreased in rodent models for stress-related disorders at least partly through an elevated level of glucocorticoids. On the other hand, the mood stabilizer lithium (Li) commonly used for their treatment increases it. This effect is thought to be one of the therapeutic actions of Li, but the molecular mechanism has been poorly understood. Here we established the culture system of adult rat dentate gyrus-derived neural precursor cells (ADPs) and examined the effects of dexamethasone (DEX), an agonist of glucocorticoids receptor, and Li on ADP proliferation. It is possible for ADP to be a type 2a cell, which corresponds to the second stage in a model of four differentiation stages in adult hippocampal neural precursor cells. DEX decreased ADP proliferation, but Li did not have any effect on it. However, Li recovered ADP proliferation decreased by DEX. The recovery effect of Li was abolished by quercetin, an inhibitor of beta-catenin/TCF pathway. The intranuclear translocation of beta-catenin and expression of cyclin D1 are reciprocally regulated by DEX and Li in a way similar to proliferation. In addition, DEX increased the phosphorylation of Tyr(216), which renders glycogen synthase kinase-3beta (GSK-3beta) active on it. These results suggest that GSK-3beta and beta-catenin/TCF pathway might be important in the reciprocal effects between DEX and Li on ADP proliferation and are new targets of therapeutic agents for stress-related disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1740-634X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
805-15
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:19005466-Active Transport, Cell Nucleus, pubmed-meshheading:19005466-Adult Stem Cells, pubmed-meshheading:19005466-Aminophenols, pubmed-meshheading:19005466-Animals, pubmed-meshheading:19005466-Cell Differentiation, pubmed-meshheading:19005466-Cell Nucleus, pubmed-meshheading:19005466-Cell Proliferation, pubmed-meshheading:19005466-Cells, Cultured, pubmed-meshheading:19005466-Cyclin D1, pubmed-meshheading:19005466-Dentate Gyrus, pubmed-meshheading:19005466-Dexamethasone, pubmed-meshheading:19005466-Glycogen Synthase Kinase 3, pubmed-meshheading:19005466-Lithium, pubmed-meshheading:19005466-Male, pubmed-meshheading:19005466-Maleimides, pubmed-meshheading:19005466-Neurogenesis, pubmed-meshheading:19005466-Phosphorylation, pubmed-meshheading:19005466-Quercetin, pubmed-meshheading:19005466-Rats, pubmed-meshheading:19005466-Rats, Sprague-Dawley, pubmed-meshheading:19005466-Stem Cells, pubmed-meshheading:19005466-TCF Transcription Factors, pubmed-meshheading:19005466-beta Catenin
pubmed:year
2009
pubmed:articleTitle
Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway.
pubmed:affiliation
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan. shuboku@med.hokudai.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't