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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-11-13
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pubmed:abstractText |
Mesenchymal stem cells (MSC) have multilineage differentiation and immunomodulatory capacities and are potentially useful for therapeutic applications, such as tissue regeneration and control of alloreactivity. MSC are present in most tissues including the transplantable organs. It is therefore unavoidable that MSC will be exposed to immunosuppressive drugs in a clinical transplantation setting. The molecular targets of these drugs are expressed in MSC, but the effect of their inhibition on MSC functioning is unknown.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1534-6080
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1283-91
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pubmed:dateRevised |
2009-6-23
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pubmed:meshHeading |
pubmed-meshheading:19005411-Apoptosis,
pubmed-meshheading:19005411-Cell Differentiation,
pubmed-meshheading:19005411-Cell Proliferation,
pubmed-meshheading:19005411-Cell Survival,
pubmed-meshheading:19005411-Cells, Cultured,
pubmed-meshheading:19005411-Dose-Response Relationship, Drug,
pubmed-meshheading:19005411-Enzyme Inhibitors,
pubmed-meshheading:19005411-Humans,
pubmed-meshheading:19005411-Immunosuppression,
pubmed-meshheading:19005411-Immunosuppressive Agents,
pubmed-meshheading:19005411-Mesenchymal Stem Cells,
pubmed-meshheading:19005411-Mycophenolic Acid,
pubmed-meshheading:19005411-Sirolimus,
pubmed-meshheading:19005411-Tacrolimus,
pubmed-meshheading:19005411-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and rapamycin.
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pubmed:affiliation |
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. M.Hoogduijn@erasmusmc.nl
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pubmed:publicationType |
Journal Article
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