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19004630
Source:
http://linkedlifedata.com/resource/pubmed/id/19004630
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0243077
pubmed:issue
24
pubmed:dateCreated
2008-11-25
pubmed:abstractText
A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Ions
,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers
,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed-author:AtwalKarnailK
,
pubmed-author:ConderMary LeeML
,
pubmed-author:FinlayHeather JHJ
,
pubmed-author:HallJ CJC
,
pubmed-author:HuynhTramT
,
pubmed-author:Jenkins-WestTonyaT
,
pubmed-author:LevesquePaulP
,
pubmed-author:LloydJohnJ
,
pubmed-author:PittC GCG
,
pubmed-author:VaccaroWayneW
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6381-5
pubmed:meshHeading
pubmed-meshheading:19004630-Animals
,
pubmed-meshheading:19004630-Atrial Fibrillation
,
pubmed-meshheading:19004630-Cell Line
,
pubmed-meshheading:19004630-Chemistry, Pharmaceutical
,
pubmed-meshheading:19004630-Drug Design
,
pubmed-meshheading:19004630-Humans
,
pubmed-meshheading:19004630-Ions
,
pubmed-meshheading:19004630-Mice
,
pubmed-meshheading:19004630-Models, Chemical
,
pubmed-meshheading:19004630-Potassium Channel Blockers
,
pubmed-meshheading:19004630-Potassium Channels, Voltage-Gated
,
pubmed-meshheading:19004630-Pyrimidines
,
pubmed-meshheading:19004630-Stereoisomerism
,
pubmed-meshheading:19004630-Structure-Activity Relationship
pubmed:year
2008
pubmed:articleTitle
Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).
pubmed:affiliation
Bristol-Myers Squibb, Route 206 & Provinceline Road, PO Box 4000, Princeton, NJ 08543-4000, USA. wayne.vaccaro@bms.com
pubmed:publicationType
Journal Article