Linked Life Data

19004621

Source:http://linkedlifedata.com/resource/pubmed/id/19004621

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-2-2
pubmed:abstractText
Cyclooxygenase-2 (COX2) plays an important role in the production of prostaglandin E2 (PGE2), which is made by epidermal keratinocytes in response to ultraviolet radiation (UVR). PGE2 is important for the proliferation and melanogenesis of epidermal melanocytes, the loss of which leads to vitiligo. COX2-1195A>G, -765G>C, and -8473T>C polymorphisms may influence the mRNA levels of COX2 and affect the production of PGE2 subsequently. Therefore, we supposed that these polymorphisms may be associated with vitiligo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0923-1811
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-81
pubmed:meshHeading
pubmed-meshheading:19004621-Adolescent, pubmed-meshheading:19004621-Adult, pubmed-meshheading:19004621-Aged, pubmed-meshheading:19004621-Aged, 80 and over, pubmed-meshheading:19004621-Alleles, pubmed-meshheading:19004621-Base Sequence, pubmed-meshheading:19004621-Case-Control Studies, pubmed-meshheading:19004621-Child, pubmed-meshheading:19004621-Child, Preschool, pubmed-meshheading:19004621-China, pubmed-meshheading:19004621-Cyclooxygenase 2, pubmed-meshheading:19004621-DNA, pubmed-meshheading:19004621-Dinoprostone, pubmed-meshheading:19004621-Female, pubmed-meshheading:19004621-Genetic Predisposition to Disease, pubmed-meshheading:19004621-Genotype, pubmed-meshheading:19004621-Humans, pubmed-meshheading:19004621-Infant, pubmed-meshheading:19004621-Infant, Newborn, pubmed-meshheading:19004621-Keratinocytes, pubmed-meshheading:19004621-Male, pubmed-meshheading:19004621-Middle Aged, pubmed-meshheading:19004621-Polymorphism, Restriction Fragment Length, pubmed-meshheading:19004621-Risk Factors, pubmed-meshheading:19004621-Vitiligo, pubmed-meshheading:19004621-Young Adult
pubmed:year
2009
pubmed:articleTitle
Association of COX2 functional polymorphisms and the risk of vitiligo in Chinese populations.
pubmed:affiliation
Department of Dermatology of Xijing Hospital, Fourth Military Medical University, Xi'an, China.
pubmed:publicationType
Journal Article