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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-2
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pubmed:abstractText |
Development of NKT cells was shown to depend on lymphotoxin (LT) and IL-15 signaling pathways as well as on cytokine receptor common gamma chain. After positive selection, NKT-cell precursors transit through progressive maturation stages including proliferative expansion within the NK1.1(-) window. The transcription factors that integrate different signaling pathways into different stages of NKT-cell development are not well characterized. Here, we show that the Rel/NF-kappaB family member RelA regulates the NK1.1(-) to NK1.1(+) transition during NKT-cell development. RelA is also required for both IL-15- and IL-7-induced proliferation of CD44(hi)NK1.1(-) NKT-cell precursors. Activation of the invariant NKT-cell receptor induces both IL-15 receptor alpha and gamma chains' expression in an NF-kappaB-dependent manner, suggesting a molecular mechanism by which NF-kappaB regulates NKT-cell development. NF-kappaB also regulates TCR-induced expression of LT-alpha and LT-beta within NKT cells. In contrast to previous reports, however, we show that LT signaling is dispensable for thymic NKT-cell development but is essential for their colonization of peripheral organs such as liver.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin Receptor Common gamma...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15 Receptor alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/guanosine 3',5'-polyphosphate...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1521-4141
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3508-19
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pubmed:meshHeading |
pubmed-meshheading:19003818-Animals,
pubmed-meshheading:19003818-Antigens, CD44,
pubmed-meshheading:19003818-Cell Differentiation,
pubmed-meshheading:19003818-Cell Proliferation,
pubmed-meshheading:19003818-Cells, Cultured,
pubmed-meshheading:19003818-Interleukin Receptor Common gamma Subunit,
pubmed-meshheading:19003818-Interleukin-15,
pubmed-meshheading:19003818-Interleukin-15 Receptor alpha Subunit,
pubmed-meshheading:19003818-Interleukin-7,
pubmed-meshheading:19003818-Ligases,
pubmed-meshheading:19003818-Lymphotoxin-alpha,
pubmed-meshheading:19003818-Mice,
pubmed-meshheading:19003818-NF-kappa B,
pubmed-meshheading:19003818-Natural Killer T-Cells,
pubmed-meshheading:19003818-Protein Binding,
pubmed-meshheading:19003818-Protein Subunits,
pubmed-meshheading:19003818-Receptors, Antigen, T-Cell,
pubmed-meshheading:19003818-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells.
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pubmed:affiliation |
Leibniz-Institute for Age Research, Fritz-Lipmann-Institute, Jena, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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