Source:http://linkedlifedata.com/resource/pubmed/id/19001504
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
Pt 23
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pubmed:dateCreated |
2008-11-21
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pubmed:abstractText |
Neuromuscular junctions (NMJs) are normally thought to comprise three major cell types: skeletal muscle fibres, motor neuron terminals and perisynaptic terminal Schwann cells. Here we studied a fourth population of junctional cells in mice and rats, revealed using a novel cytoskeletal antibody (2166). These cells lie outside the synaptic basal lamina but form caps over NMJs during postnatal development. NMJ-capping cells also bound rPH, HM-24, CD34 antibodies and cholera toxin B subunit. Bromodeoxyuridine incorporation indicated activation, proliferation and spread of NMJ-capping cells following denervation in adults, in advance of terminal Schwann cell sprouting. The NMJ-capping cell reaction coincided with expression of tenascin-C but was independent of this molecule because capping cells also dispersed after denervation in tenascin-C-null mutant mice. NMJ-capping cells also dispersed after local paralysis with botulinum toxin and in atrophic muscles of transgenic R6/2 mice. We conclude that NMJ-capping cells (proposed name 'kranocytes') represent a neglected, canonical cellular constituent of neuromuscular junctions where they could play a permissive role in synaptic regeneration.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9533
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3901-11
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pubmed:meshHeading |
pubmed-meshheading:19001504-Animals,
pubmed-meshheading:19001504-Basement Membrane,
pubmed-meshheading:19001504-Cell Proliferation,
pubmed-meshheading:19001504-Cells, Cultured,
pubmed-meshheading:19001504-Immunohistochemistry,
pubmed-meshheading:19001504-Mice,
pubmed-meshheading:19001504-Mice, Inbred C57BL,
pubmed-meshheading:19001504-Motor Neurons,
pubmed-meshheading:19001504-Neuromuscular Junction,
pubmed-meshheading:19001504-Presynaptic Terminals,
pubmed-meshheading:19001504-Rats,
pubmed-meshheading:19001504-Rats, Sprague-Dawley,
pubmed-meshheading:19001504-Schwann Cells
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pubmed:year |
2008
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pubmed:articleTitle |
Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions.
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pubmed:affiliation |
Euan MacDonald Centre for Motor Neurone Disease Research, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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