Source:http://linkedlifedata.com/resource/pubmed/id/19000143
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2008-12-4
|
| pubmed:abstractText |
We studied the importance of human leucocyte antigen (HLA)-A, -B and -DRB1 high-resolution matching on the outcome of haematopoietic stem cell transplantation (HSCT) with matched unrelated donors (MUDs) vs single allele-mismatched unrelated donors. Fifty consecutive HSCT patients receiving an HLA-A, -B or -DR allele-level-mismatched unrelated graft (mmUD) were compared with a matched cohort of 100 patients with an HLA-A, -B and -DR-MUD. Rejection occurred in seven patients (14%) in the mmUD group and in four patients (4%) in the MUD group (P = 0.04), but this was mainly an effect of HLA-C mismatch. The cumulative incidence of acute graft vs host disease (GVHD) grades II-IV were 61%, 26% and 33% in the class I mmUD, class II mmUD and MUD groups, respectively. In multivariate analysis, HLA class I mismatch was associated with an increased risk of acute GVHD grades II-IV (2.09, P = 0.007) and transplant-related mortality (TRM) (1.99, P = 0.06). The 5-year overall survival was 81% in patients with a class II allele-mismatched donor compared with 52% (P = 0.025) and 50% (P = 0.017) in patients with a class I mismatch and a MUD. In multivariate analysis, HLA class II allele mismatch was associated with improved survival (3.38, P = 0.019). Relapse-free survival were 53%, 37% and 42% in patients with a class II mmUD, class I mmUD and a MUD, respectively (not significant). An HLA-C or -DQ mismatch had no significant impact on survival, TRM and relapse. In conclusion, compared with MUD, HLA class I allele mmUD had an increased risk of acute GVHD and TRM.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1399-0039
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
549-58
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19000143-Adolescent,
pubmed-meshheading:19000143-Adult,
pubmed-meshheading:19000143-Alleles,
pubmed-meshheading:19000143-Child,
pubmed-meshheading:19000143-Child, Preschool,
pubmed-meshheading:19000143-Female,
pubmed-meshheading:19000143-Graft vs Host Disease,
pubmed-meshheading:19000143-HLA-A Antigens,
pubmed-meshheading:19000143-HLA-B Antigens,
pubmed-meshheading:19000143-HLA-DR Antigens,
pubmed-meshheading:19000143-HLA-DRB1 Chains,
pubmed-meshheading:19000143-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19000143-Histocompatibility,
pubmed-meshheading:19000143-Humans,
pubmed-meshheading:19000143-Infant,
pubmed-meshheading:19000143-Male,
pubmed-meshheading:19000143-Middle Aged,
pubmed-meshheading:19000143-Tissue Donors,
pubmed-meshheading:19000143-Treatment Outcome,
pubmed-meshheading:19000143-Young Adult
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Outcome of haematopoietic stem cell transplantation in patients transplanted with matched unrelated donors vs allele-mismatched donors: a single centre study.
|
| pubmed:affiliation |
Department of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|