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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-3-22
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pubmed:abstractText |
This study was performed to evaluate hypothalamic-pituitary hormone regulation in patients with familial amyloidotic polyneuropathy. Twenty-two patients without clinically overt endocrinological dysfunction were studied. A thyrotropin-releasing hormone test revealed abnormal growth hormone regulation in 9 of 17 (53%) patients, and abnormal prolactin regulation in 9 of 18 (50%) patients. Abnormalities in either growth hormone or prolactin regulation were found in 12 of 17 (71%) patients. Serum somatomedin C levels were normal in all 22 patients. In 3 of 18 (17%) patients the plasma arginine vasopressin levels were low relative to the serum osmolality levels. Thus abnormalities in hypothalamic-pituitary hormone regulation may be common in familial amyloidotic polyneuropathy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0954-6820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
229
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1899879-Amyloidosis,
pubmed-meshheading:1899879-Arginine Vasopressin,
pubmed-meshheading:1899879-Female,
pubmed-meshheading:1899879-Growth Hormone,
pubmed-meshheading:1899879-Humans,
pubmed-meshheading:1899879-Hypothalamo-Hypophyseal System,
pubmed-meshheading:1899879-Insulin-Like Growth Factor I,
pubmed-meshheading:1899879-Male,
pubmed-meshheading:1899879-Middle Aged,
pubmed-meshheading:1899879-Osmolar Concentration,
pubmed-meshheading:1899879-Polyneuropathies,
pubmed-meshheading:1899879-Prolactin,
pubmed-meshheading:1899879-Thyrotropin-Releasing Hormone
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pubmed:year |
1991
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pubmed:articleTitle |
Assessment of hypothalamic-pituitary function in patients with familial amyloidotic polyneuropathy.
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pubmed:affiliation |
Department of Internal Medicine, Chemistry, University of Umeå, Sweden.
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pubmed:publicationType |
Journal Article
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